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855440 HCH1

855440

HCH1

Hch1p

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition Hch1p

研究结论

Date Results Publications
2018-11-24 11:03:00 Phosphorylation of human Hsp90alpha at the highly conserved tyrosine (Y) 627 affects it conformation and function. Y627 is not phosphorylated in yeast, but study demonstrated that the non-conserved yeast co-chaperone, Hch1, modifies yeast Hsp90 (Hsp82) through Y606E phosphomimetic mutation raising the possibility that this post-translational modification in higher eukaryotes represents an evolutionary substitution for ... 28537252
2014-07-12 11:00:00 The work here suggests that both Hch1p and Aha1p regulate Hsp90 function through interaction with the catalytic loop but do so in different ways. 24726918
2013-05-11 12:40:00 The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922. 23166640

名称对应

Type IDs
Gene
UniProtKB-ID: HCH1_YEAST
UniprotKB: P53834
UniParc: UPI000013BA6E
EMBL: BK006947, Z71557
EnsemblGenome: YNL281W
KO: sce:YNL281W
Nucleutide sequences
EMBL-CDS: DAA10279.1, CAA96193.1
Gene_ORFName: N0589
EnsemblGenome_TRS: YNL281W_mRNA
Protein sequencees
EnsemblGenome_PRO: YNL281W
RefSeq: NP_014118.1
Others
UniRef100: UniRef100_P53834
UniRef90: UniRef90_P53834
UniRef50: UniRef50_P53834

全选

研究热度
发表文献
热点单位
排名 科研单位 文献
1

University of Toronto

4
2

University of Alberta

4
3

University of Idaho

3
4

University of Minnesota-Twin Cities

2
5

Howard Hughes Medical Institute

2
热点人员
排名 研究人员 文献
1

Charles Boone

4
2

Paul LaPointe

4
3

Yiqun Chen

3
4

Raamesh Deshpande

3
5

Hongwei Zhu

3
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