| Type | Description |
|---|---|
| Definition | multifunctional nuclease RAD27 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 12:58:00 | Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins. | 31937519 |
| 2019-08-31 11:31:00 | By conditionally depleting lagging-strand nucleases and directly analyzing Okazaki fragments synthesized in vivo in Saccharomyces cerevisiae, we conduct a systematic evaluation of the impact of Rad27, Dna2 and Exo1 on lagging-strand synthesis. We find that Rad27 processes the majority of lagging-strand flaps, with a significant additional contribution from Exo1 but not from Dna2. | 30541106 |
| 2019-07-27 13:03:00 | Overexpression of RAD27 impairs DNA replication leading to S phase delay, DNA damage and mutation in a manner that is dependent on its interaction with PCNA. | 29741650 |
| 2019-07-27 12:23:00 | Data show that unlike short-flap substrates, which are bound, bent and cleaved within the first encounter between Flap Endonuclease 1 (FEN1) and DNA, long-flap substrates can escape cleavage even after DNA binding and bending. | 29420814 |
| 2017-12-30 10:15:00 | Rad2 and rad27 overexpression increases genomic instability in yeast. Rad2 and Rad27 causes DNA breaks that are processed by different repair functions. | 28704715 |
| Type | IDs |
|---|---|
| Synonymous | ERC11, FEN1, RTH1 |
| Gene |
UniProtKB-ID:
FEN1_YEAST
UniprotKB:
P26793
UniParc:
UPI0000050E10
EMBL:
BK006944,
Z28113,
S93804
EnsemblGenome:
YKL113C
KO:
sce:YKL113C
|
| Nucleutide sequences |
EMBL-CDS:
CAA81953.1,
AAB21998.1,
DAA09045.1
Gene_ORFName:
YKL510
EnsemblGenome_TRS:
YKL113C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YKL113C
RefSeq:
NP_012809.1
|
| Others |
UniRef100:
UniRef100_C7GVJ8
UniRef90:
UniRef90_B3LQY3
UniRef50:
UniRef50_Q75DS8
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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