| Type | Description |
|---|---|
| Definition | double-stranded DNA-dependent ATPase |
| Date | Results | Publications |
|---|---|---|
| 2018-04-21 12:06:00 | Study revealed that Irc3 - a dsDNA dependent ATPase of the Superfamily II- is essential for yeast mtDNA maintenance. irc3Delta mutant yeast cells accumulated double-stranded breaks in mtDNA and lose the wild-type mitochondrial genome in the course of a few generations of growth on glucose-containing media. These results demonstrate that Irc3 is a mitochondrial branch migration enzyme. | 27194389 |
| 2017-12-23 11:01:00 | Irc3 disrupts partially triple-stranded DNA structures in an ATP-dependent manner. Our kinetic experiments indicate that the rate of ATP hydrolysis by Irc3 is dependent on the length of the double-stranded DNA cosubstrate. | 29113022 |
| 2015-01-31 10:19:00 | The data suggest that Irc3p is required to avoid the accumulation of dsDNA breaks that could irreversibly damage the mitochondrial genetic system. | 25389272 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
IRC3_YEAST
UniprotKB:
Q06683
UniParc:
UPI000006C0CC
EMBL:
BK006938,
U32517
EnsemblGenome:
YDR332W
KO:
sce:YDR332W
|
| Nucleutide sequences |
EMBL-CDS:
AAB64767.1,
DAA12174.1
EnsemblGenome_TRS:
YDR332W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDR332W
RefSeq:
NP_010619.3
|
| Others |
UniRef100:
UniRef100_Q06683
UniRef90:
UniRef90_Q06683
UniRef50:
UniRef50_Q06683
|