| Type | Description |
|---|---|
| Definition | sphingolipid homeostasis protein ORM2 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-28 11:12:00 | Orm2 degradation is initiated by phosphorylation, which triggers its ER export. Once on Golgi and endosomes, Orm2 is poly-ubiquitinated by the membrane-embedded Dsc ubiquitin ligase complex. Cdc48/VCP then extracts ubiquitinated Orm2 from membranes, which is tightly coupled to the proteasomal degradation of Orm2. | 31368600 |
| 2013-09-28 11:16:00 | Data indicate that Orm1 and Orm2 proteins respond to feedback signals from the sphingolipid synthesis pathway. | 23737533 |
| 2013-09-14 11:42:00 | Npr1-phosphorylated Orm1 and Orm2 stimulate de novo synthesis of complex sphingolipids downstream of serine palmitoyltransferase. | 23363605 |
| 2012-12-08 10:07:00 | Orm1 and Orm2 regulated the synthesis of sphingolipid. | 22328531 |
| 2012-10-13 10:38:00 | Data show a mechanism through which the conserved Pkh-Ypk kinase cascade and Cdc55-PP2A facilitate rapid, transient sphingolipid production in response to heat stress through Orm protein phosphoregulation. | 22535525 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ORM2_YEAST
UniprotKB:
Q06144
UniParc:
UPI000006B127
EMBL:
BK006945,
U19028,
AY692908
EnsemblGenome:
YLR350W
KO:
sce:YLR350W
|
| Nucleutide sequences |
EMBL-CDS:
AAB67252.1,
AAT92927.1,
DAA09654.1
EnsemblGenome_TRS:
YLR350W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YLR350W
RefSeq:
NP_013454.1
|
| Others |
UniRef100:
UniRef100_Q06144
UniRef90:
UniRef90_Q06144
UniRef50:
UniRef50_Q06144
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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