Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
[No authors listed]
摘要
The microRNA-183/96/182 cluster is highly expressed in the retina and other sensory organs. To uncover its in vivo functions in the retina, we generated a knockout mouse model, designated "miR-183C(GT/GT)," using a gene-trap embryonic stem cell clone. We provide evidence that inactivation of the cluster results in early-onset and progressive synaptic defects of the photoreceptors, leading to abnormalities of scotopic and photopic electroretinograms with decreased b-wave amplitude as the primary defect and progressive retinal degeneration. In addition, inactivation of the miR-183/96/182 cluster resulted in global changes in retinal gene expression, with enrichment of genes important for synaptogenesis, synaptic transmission, photoreceptor morphogenesis, and phototransduction, suggesting that the miR-183/96/182 cluster plays important roles in postnatal functional differentiation and synaptic connectivity of photoreceptors.
KEYWORDS: {{ getKeywords(articleDetailText.words) }}
基因功能
- {{$index+1}}.{{ gene }}
基因
Mthfsl, Ildr2, Copg2os2, Rell1, Lrrc8c, Mirc35hg, Meig1, Mbnl2, Mthfs, Galnt7, Lmo1, Cald1, Cbr3, Tmbim6, Msra, H2, Abca1, Ache, Chrnb1, Rasa2, Adssl1, Prelp, Iltifb, Aox1, Aqp1, B2m, Bcl6, Serping1, C1qc, C4b, Cacna2d3, Casp7, Cd44, Cd9, Cfi, Col4a3, Cp, Cr1l, Crym, Ctbp2, Cttn, Dlg4, Doc2b, Edn2, Emx1, Enc1, Ephb3, Ephx2, Eri3, Folr1, Opn1mw, Gfap, Glycam1, Gna14, Gnb2, Pdpn, Gpm6b, Ptpn6, Hdc, Hsd17b2, Sdc2, Mdfic, Kifc3, Laptm5, Gzmm, Arr3, Lyz2, Mab21l1, Marcks, Mcl1, Mcm3, Mef2c, Mesp1, Myo10, Slc25a15, Osmr, Lgals3bp, Psen2, Tmsb4x, Pygm, Rab3d, Rps17, S100a1, S100a6, Ccl9, Exoc4, Sema3b, Sez6, Sh2d1a, Slc12a4, Slc16a2, Slc19a1, Slc1a1, Slc6a2, Dtx4, Klhl29, Snx30, Sdc3, Mtss1, Rho, Plekhg1, Tcea3, Nav1, Hkdc1, Morf4l1, Rapgef5, Thra, Clptm1l, Scara3, Tnfaip2, Tnfrsf1a, Tnnt2, Tuft1, Vamp8, Vhl, Ezr, Vim, Gramd4, Zik1, Lrp4, Plppr4, Gckr, Sel1l3, Slc4a5, Prtg, Faim, Kctd12, Rspo2, Rai2, Adamts19, Slc35a1, Wdr63, Kcne2, Cd300lf, Mios, Slc27a4, Arhgef40, Gpr152, Slc9a3r1, Rpl13, Podxl, Tada1, Agpat3, Bcar3, Slc39a1, Pdlim4, Nrcam, 9330159M07Rik, A430035B10Rik, Myo1d, Pabpn1l, Mir182, Mir183, Crim1, Il22, Tmem141, Pnrc2, Pdlim3, Cd164, Elovl2, Fxyd1, Htra1, Morf4l2, Fads2, Mgst1, Rab37, Nectin3, Rnf130, Fads3, Nmi, Tmem176b, Asph, Tmem176a, Rps10, Paip2, Tmem86a, Tubb6, Rbm28, Mrpl53, Nadk2, Pink1, Cnot8, 1700007K13Rik, Bst2, Bhlhb9, Mkrn2os, Reep6, Cpne3, Adgra3, Kazn, Rarres2, Isyna1, Antxr2, Tnfrsf13c, Phf10, Mir96, Zfp655, Adipor1, Marveld3, Usp20, Ttll11, Cds1, Dynlrb2, Rsph9, Dock8, Tax1bp3, Ssbp4, Cep83, Ttyh3, Rilpl2, Rhoj, Chrdl1, Mtmr14, Pid1
原始数据
| Sample name | Organism | Experiment title | Sample type | Library instrument | Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| {{attr}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| {{ dataList.sampleTitle }} | {{ dataList.organism }} | {{ dataList.expermentTitle }} | {{ dataList.sampleType }} | {{ dataList.libraryInstrument }} | {{ showAttributeName(index,attr,dataList.attributes) }} | |||||||||||||||||||||||||||||||||||||||||||||||||
文献解读
| {{ list.authorName }} {{ list.authorName }} |
