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28169 Agpat3

28169

Agpat3

1-acylglycerol-3-phosphate O-acyltransferase 3

protein-coding

Mus musculus

基因描述

Type Description
Definition 1-acylglycerol-3-phosphate O-acyltransferase 3

研究结论

Date Results Publications
2019-07-20 10:16:00 It identified lysophosphatidic acid acyltransferase (LPAAT)3 as an enzyme that was upregulated in myoblasts during in vitro differentiation and selectively incorporated DHA intophosphatidylcholine and phosphatidylethanolamine. 29284664
2017-08-12 10:16:00 Data suggest that PL-DHA (docosahexaenoic acid-containing phospholipids) contribute to visual function by maintaining disc shape in photoreceptor cells; PL-DHA disappears from outer segment in LPAAT3-knockout mice; LPAAT3-knockout mice exhibit abnormalities in retinal layers, disordered disc morphology in photoreceptor cells, and impaired visual function. 28578316
2017-08-12 10:16:00 Data suggest that LPAAT3 is required for producing docosahexaenoic acid- (DHA)-containing phospholipids in various tissues, such as the testes and retina; LPAAT3-knockout mice exhibit severe male infertility with abnormal sperm morphology; lack of LPAAT3 causes drastic reduction of DHA-containing phospholipids in spermatids with excess cytoplasm around the sperm head. 28578315
2012-03-03 11:43:00 The induction of LPAAT3 during germ cell development critically contributes to the accumulation of PUFAs in testicular phospholipids, thereby possibly affecting sperm cell production. 21968070
2010-01-21 00:00:00 mAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption 16150824

名称对应

Type IDs
Synonymous AW061257, AW493985, D10Jhu12e, lpaat3
Gene
UniProtKB-ID: PLCC_MOUSE
UniprotKB: Q9D517
UniParc: UPI000002A047
EMBL: AY167588, BC052382, AK075715, AK076414, AB377215, AK015906, AK030607, CH466553, BC058519
Ensembl: ENSMUSG00000001211
KO: mmu:28169
Nucleutide sequences
EMBL-CDS: BAC36329.1, EDL31739.1, EDL31740.1, AAH58519.1, BAB30025.2, BAH59614.1, BAC27043.1, AAN75574.1, EDL31738.1, BAC35905.1, EDL31742.1, AAH52382.1
Ensembl_TRS: ENSMUST00000166360, ENSMUST00000001240, ENSMUST00000105388, ENSMUST00000105390, ENSMUST00000105387, ENSMUST00000105389
Protein sequencees
Ensembl_PRO: ENSMUSP00000101028, ENSMUSP00000132954, ENSMUSP00000001240, ENSMUSP00000101026, ENSMUSP00000101027, ENSMUSP00000101029
RefSeq: XP_006513779.1, XP_006513786.1, XP_006513782.1, XP_030100970.1, XP_006513784.1, XP_036011691.1, XP_006513780.1, XP_006513783.1, XP_006513785.1, NP_443747.2, XP_006513781.1
Others
UniRef100: UniRef100_Q9D517
UniRef90: UniRef90_Q9NRZ7
UniRef50: UniRef50_Q9NRZ7
UniGene: Mm.141230
CCDS: CCDS23963.1

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