| Type | Description |
|---|---|
| Definition | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:30:00 | The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. | 31943697 |
| 2018-11-17 10:54:00 | Network-based analysis suggests a role for Elovl2 in glucose-induced insulin secretion. Elovl2 silencing decreased glucose-stimulated insulin secretion in mouse and human beta cell lines. | 28377873 |
| 2017-08-26 11:27:00 | The proportion of DHA in the liver and serum of the Elovl2(-/-) offspring was significantly lower than in the Elovl2(+/+) offspring. Remarkably, the DHA level in the Elovl2(+/-) offspring nursed by DHA-free-fed Elovl2(-/-) mothers was almost as high as in +/+ pups delivered by +/+ mothers, suggesting that endogenous synthesis in the offspring can compensate for maternal DHA deficiency. | 27864326 |
| 2014-12-20 12:05:00 | Liver docosahexanoic acid synthesis (via ELOVL2), in addition to controlling de novo lipogenesis, also regulates lipid storage and fat mass expansion in an SREBP-1c-independent fashion. | 24489111 |
| 2011-05-07 11:10:00 | heterozygous Elovl2(+/-) male mice exhibited haploinsufficiency, with reduced levels of C28:5 and C30:5n-6 PUFAs, which gave rise to impaired formation and function of haploid spermatides. | 21106902 |
| Type | IDs |
|---|---|
| Synonymous | AI317360, Ssc2 |
| Gene |
UniProtKB-ID:
ELOV2_MOUSE,
A0A0R4J1P7_MOUSE,
Q543J1_MOUSE
UniprotKB:
Q9JLJ4,
A0A0R4J1P7,
Q543J1
UniParc:
UPI000016931B,
UPI0000003F98
EMBL:
AF170908,
AK014803,
BC098215,
AK050397,
AK029855,
AC158538,
AK044770
Ensembl:
ENSMUSG00000021364
KO:
mmu:54326
|
| Nucleutide sequences |
EMBL-CDS:
AAF72573.1,
BAC26646.1,
BAB29559.1,
BAC32079.1,
BAC34236.1,
AAH98215.1
Ensembl_TRS:
ENSMUST00000021793,
ENSMUST00000117096
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021793,
ENSMUSP00000114112
RefSeq:
NP_001298050.1,
NP_062296.1
|
| Others |
UniRef100:
UniRef100_Q9JLJ4
UniRef90:
UniRef90_Q9JLJ4
UniRef50:
UniRef50_Q9NXB9
UniGene:
Mm.2567
CCDS:
CCDS36639.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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