| Type | Description |
|---|---|
| Definition | fatty acid desaturase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:15:00 | Reduced delta-6 desaturase activity partially protects against high-fat diet-induced impairment in whole-body glucose tolerance. | 30928647 |
| 2019-12-07 11:20:00 | Describe a novel SNP in the Fads2 gene encoding Delta6-desaturase, a key enzyme in the metabolic pathways of polyunsaturated fatty acids. The allele frequencies of Fads2 were significantly different in two lines of mice divergently selected for either high or low basal metabolic rate. | 30818386 |
| 2018-08-18 10:13:00 | Data (including data from studies using knockout mice) suggest that increased dietary intake of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) differentially affects activity of D5D/Fads1 and D6D/Fads2 in specific tissues. | 28697636 |
| 2018-06-02 10:41:00 | In comparison, Fads2-/- and WT mice fed AD showed minimal differences in n-6 PUFA content in serum and WAT, despite having significantly more AA than CD-fed mice. No differences in gene expression for common inflammatory adipokines (e.g. Mcp-1, Ccl5, Tnfalpha) or key regulators of eicosanoid production (e.g. Cox-2, Alox-12, Alox-15) were detected in WAT between any of the diet and genotype groups | 29031400 |
| 2018-03-10 12:03:00 | In this study, an obvious hepatic lipid accumulation was observed in essential fatty acid deficiency (EFAD) mice treated with a FADS2 inhibitor. FADS2 inhibition in the EFAD state reduced secretion of very low-density lipoprotein (VLDL) and markedly diminished Mead acid in phosphatidylcholine (PC) in the liver and plasma. | 29353041 |
| Type | IDs |
|---|---|
| Synonymous | 2900042M13Rik, Fadsd2 |
| Gene |
UniProtKB-ID:
FADS2_MOUSE
UniprotKB:
Q9Z0R9
UniParc:
UPI00000223ED
EMBL:
AF126798,
BC057189,
AK143524
Ensembl:
ENSMUSG00000024665
KO:
mmu:56473
|
| Nucleutide sequences |
EMBL-CDS:
AAD20017.1,
AAH57189.1,
BAE25416.1
Ensembl_TRS:
ENSMUST00000025567
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025567
RefSeq:
NP_062673.1
|
| Others |
UniRef100:
UniRef100_Q9Z0R9
UniRef90:
UniRef90_Q9Z122
UniRef50:
UniRef50_Q9Z122
UniGene:
Mm.38901
CCDS:
CCDS29571.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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