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19165 Psen2

19165

Psen2

presenilin 2

protein-coding

Mus musculus

基因描述

Type Description
Definition presenilin 2

研究结论

Date Results Publications
2021-01-09 13:26:00 Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition. 31862541
2019-04-27 10:56:00 PS1- and PS2-dependent substrate processing in murine cells lacking presenilins (PSs) or stably re-expressing human PS1 or PS2 in an endogenous PS-null (PSdKO) background, were studied. 28994238
2019-04-20 11:01:00 Study uncovers a role of PS in presynaptic mechanisms, through APP cleavage and regulation of Syt7, that highlights aberrant synaptic vesicle processing as a possible new pathway in Alzheimer's disease. 30429473
2019-02-09 12:32:00 The altered expressions of hippocampal microRNAs were associated to the imbalance between neurotoxic and neuroprotective functions and seemed to affect neurodegeneration in PSEN1/PSEN2 double knockout mice more severely than in wild-type mice. 28879407
2017-12-23 12:47:00 These observations illustrate a novel PS2-dependent means of modulating LPS-mediated immune responses and identify a functional distinction between PS1 and PS2 in innate immunity. 26081153

名称对应

Type IDs
Synonymous ALG-3, Ad4h, Alg3, PS-2, PS2, Psnl2, STM2
Gene
UniProtKB-ID: PSN2_MOUSE, Q3U4P5_MOUSE, A0A0R4J1F2_MOUSE
UniprotKB: Q61144, Q3U4P5, A0A0R4J1F2
UniParc: UPI00001D4720, UPI000016C802, UPI00000211B1, UPI00001D471F
EMBL: U57325, AF038935, AC132436, U49111, BC010403, AK014706, AK148111, U57324, AK154119
Ensembl: ENSMUSG00000010609
KO: mmu:19165
Nucleutide sequences
EMBL-CDS: AAB92660.1, BAB29514.1, AAH10403.1, AAC52935.1, AAC53311.1, AAC52937.1, BAE28350.1, BAE32386.1
Ensembl_TRS: ENSMUST00000111108, ENSMUST00000010753, ENSMUST00000111105, ENSMUST00000111106, ENSMUST00000111104
Protein sequencees
Ensembl_PRO: ENSMUSP00000106737, ENSMUSP00000010753, ENSMUSP00000106734, ENSMUSP00000106735, ENSMUSP00000106733
RefSeq: NP_001122077.1, XP_011237078.1, NP_035313.2, XP_006496775.1
Others
UniRef100: UniRef100_A0A0R4J1F2, UniRef100_Q61144, UniRef100_Q3U4P5
UniRef90: UniRef90_Q61144, UniRef90_H0UX54
UniRef50: UniRef50_Q61144, UniRef50_P49810-2
UniGene: Mm.330850
CCDS: CCDS15567.1

全选

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