| Type | Description |
|---|---|
| Definition | lysosomal-associated protein transmembrane 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 11:32:00 | RUNX2 transactivated LAPTM5 gene expression and that LAPTM5 was involved in the trafficking of RANKL. These findings suggested that RUNX2 may regulate osteoclast differentiation through lysosome-associated genes that modulate RANKL trafficking in bone cells. | 31545469 |
| 2015-02-21 11:41:00 | these results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling. | 24638062 |
| 2013-01-26 10:21:00 | the pre-BCR induces the downmodulation of its own expression through induction of LAPTM5, which promotes the lysosomal transport and degradation of the intracellular pre-BCR pool and limits the supply of pre-BCR to the cell surface | 22949502 |
| 2012-11-17 11:11:00 | LAPTM5 acts as a positive modulator of inflammatory signaling pathways and hence cytokine secretion in macrophages | 22733818 |
| 2010-09-06 12:20:00 | LAPTM5 physically interacts with the B cell receptor complex and promotes its degradation in the lysosomal compartment in mouse B cells. | 20519653 |
| Type | IDs |
|---|---|
| Synonymous | E3, Stra13 |
| Gene |
UniProtKB-ID:
LAPM5_MOUSE,
Q544S4_MOUSE
UniprotKB:
Q61168,
Q544S4
UniParc:
UPI0000000AB3
EMBL:
AK171172,
AK171562,
AF364050,
AK171057,
AK171053,
AK171236,
AK171269,
AK171244,
AK171250,
AK171285,
BC020993,
AK163146,
AK171213,
AK155744,
AK171571,
U29539,
BC158032,
AK050633,
AK031802,
AK153877,
AK171575,
U51239,
AK171149,
AK172486,
AK172707,
AK089508,
AK171481,
BC055057,
AK171270
Ensembl:
ENSMUSG00000028581
KO:
mmu:16792
|
| Nucleutide sequences |
EMBL-CDS:
AAB48192.1,
AAB08976.1,
AAH20993.1,
AAH55057.1,
BAE42532.1,
BAE42356.1,
BAE42535.1,
BAE42276.1,
BAE42216.1,
BAE42368.1,
BAE37213.1,
BAE42342.1,
BAE32226.1,
BAE42527.1,
BAE42337.1,
BAE42355.1,
BAC40908.1,
BAE42292.1,
BAE43139.1,
BAE42317.1,
BAC34354.1,
BAE42214.1,
BAE42482.1,
BAE42332.1,
BAE33412.1,
AAI58033.1,
BAE43030.1,
AAK50858.1,
BAC27556.1
Ensembl_TRS:
ENSMUST00000151698
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000118415
RefSeq:
NP_034816.1
|
| Others |
UniRef100:
UniRef100_Q61168
UniRef90:
UniRef90_Q61168
UniRef50:
UniRef50_Q13571
UniGene:
Mm.271868
CCDS:
CCDS18712.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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