| Type | Description |
|---|---|
| Definition | solute carrier family 12, member 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 12:58:00 | KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria. | 31015511 |
| 2020-07-25 12:01:00 | the effect of genetic inactivation of K-Cl cotransporters KCC1 and KCC3 in a mouse model of beta-thalassemia intermedia; conclude that genetic inactivation of K-Cl cotransport can reverse red cell dehydration and partially attenuate the hematologic phenotype in a mouse model of beta-thalassemia. | 31835175 |
| 2020-02-08 12:50:00 | effect of genetic inactivation of KCC3 and KCC1 in the SAD mouse model of sickle red cell dehydration, finding decreased red cell density and improved hematological indices. | 31352162 |
| 2018-11-24 10:47:00 | data indicate that Zn(2+) acting via ZnR/GPR39 has a direct role in controlling Cl(-) absorption via upregulation of basolateral KCC1 in the colon. Moreover, colonocytic ZnR/GPR39 and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets. | 28093242 |
| 2016-05-07 11:06:00 | We show that a single mutant allele of Kcc1 induces widespread sickling and tissue damage, leading to premature death in a humanized mouse model of sickle cell disease | 26450986 |
| Type | IDs |
|---|---|
| Synonymous | AW546649, KCC1, RBCKCC1 |
| Gene |
UniProtKB-ID:
S12A4_MOUSE,
F8WIJ0_MOUSE,
Q3UDQ8_MOUSE,
Q3TWZ6_MOUSE,
Q3TPD4_MOUSE
UniprotKB:
Q9JIS8,
F8WIJ0,
Q3UDQ8,
Q3TWZ6,
Q3TPD4
UniParc:
UPI000047A82F,
UPI00000238FF,
UPI00005AC93F,
UPI00005B2088
EMBL:
AF047339,
AK165874,
AF191023,
AC159265,
AC133499,
AK159274,
AH009673,
AK164479,
AK149969,
AF121118,
AK159483
Ensembl:
ENSMUSG00000017765
KO:
mmu:20498
|
| Nucleutide sequences |
EMBL-CDS:
AAF91094.1,
AAF02444.1,
AAC32816.1,
AAF91090.1,
BAE29203.1,
BAE38430.1,
BAE35120.1,
BAE34953.1,
BAE37803.1
Ensembl_TRS:
ENSMUST00000116429,
ENSMUST00000034370
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000112130,
ENSMUSP00000034370
RefSeq:
XP_006530855.1,
NP_033221.1,
NP_001240733.1
|
| Others |
UniRef100:
UniRef100_Q9JIS8,
UniRef100_Q3TPD4,
UniRef100_F8WIJ0,
UniRef100_Q3UDQ8
UniRef90:
UniRef90_Q3UDQ8,
UniRef90_Q9JIS8,
UniRef90_F8WIJ0
UniRef50:
UniRef50_Q9JIS8
UniGene:
Mm.292447
CCDS:
CCDS22623.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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