| Type | Description |
|---|---|
| Definition | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-19 12:09:00 | EAAC1 is important for the survival of newly generated neurons in the adult brain under physiological and pathological conditions. Therefore, this study suggests that EAAC1 plays an essential role in modulating hippocampal neurogenesis. | 29720605 |
| 2019-08-03 10:22:00 | This study found high EAAT3 protein levels in the brush borders of both the distal small intestine and the renal proximal tubules. | 29303644 |
| 2018-05-19 10:45:00 | Here is reported a model of Slc1a1 loss based on an excisable STOP cassette that yields successful ablation of EAAT3 expression and function. EAAT3 loss prevents expected increases in (i) locomotor activity, (ii) stereotypy, and (iii) immediate early gene induction in the dorsal striatum following amphetamine administration. | 28507136 |
| 2017-11-11 11:59:00 | Morphine increased EAAT3 expression in the plasma membrane of medial prefrontal cortex, nucleus accumbens and ventral tegmental area but did not affect EAAT3 expression in the hippocampus. Results also suggest that EAAT3 delays the extinction of morphine-induced conditioned place preference (CPP). EAAT activation may prevent the formation of morphine-induced CPP. | 28049029 |
| 2017-11-04 12:40:00 | partial loss of the Slc1a1 gene in mice causes haploinsufficiency associated with behavioral, histological and biochemical changes that reflect an altered redox state and may promote the expression of behavioral features and inflammatory states consistent with those observed in schizophrenia. | 28886095 |
| Type | IDs |
|---|---|
| Synonymous | D130048G10Rik, EAAC1, EAAC2, EAAT3, MEAAC1 |
| Gene |
UniProtKB-ID:
EAA3_MOUSE
UniprotKB:
P51906
UniParc:
UPI00000224AA
EMBL:
CH466534,
U75217,
D43797,
U73521,
BC065099
Ensembl:
ENSMUSG00000024935
KO:
mmu:20510
|
| Nucleutide sequences |
EMBL-CDS:
AAH65099.1,
EDL41660.1,
AAB71742.1,
BAA07855.1,
AAB80694.1
Ensembl_TRS:
ENSMUST00000025875
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025875
RefSeq:
NP_033225.1
|
| Others |
UniRef100:
UniRef100_P51906
UniRef90:
UniRef90_P51907
UniRef50:
UniRef50_P51907
UniGene:
Mm.246670
CCDS:
CCDS29727.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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