| Type | Description |
|---|---|
| Definition | Fas apoptotic inhibitory molecule |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:28:00 | SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. | 32015347 |
| 2018-04-28 11:12:00 | The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal. | 27767058 |
| 2016-12-17 11:48:00 | Data indicate that FAIM is a novel regulator of insulin signalling and plays an essential role in energy homoeostasis. | 26866272 |
| 2010-05-10 11:38:00 | defined a TCR-induced FAIM/Akt/Nur77 signaling axis that is critical for modulating the apoptosis of developing thymocytes | 20178987 |
| 2010-01-21 00:00:00 | FAIM plays a novel role in modulating Fas-mediated apoptosis and acts through influencing the expression of c-FLIP and regulating the physical binding of caspase-8 to Fas. | 19300454 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
FAIM1_MOUSE,
D3Z3C1_MOUSE
UniprotKB:
Q9WUD8,
D3Z3C1
UniParc:
UPI00001F7CEA,
UPI0000023AB9
EMBL:
AF130367,
AK005762,
AC120148,
BC079662
Ensembl:
ENSMUSG00000032463
KO:
mmu:23873
|
| Nucleutide sequences |
EMBL-CDS:
AAH79662.1,
BAB24225.1,
AAD23879.1
Ensembl_TRS:
ENSMUST00000035038,
ENSMUST00000112911
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000035038,
ENSMUSP00000108532
RefSeq:
XP_036010823.1,
NP_001116323.1,
NP_035940.3
|
| Others |
UniRef100:
UniRef100_Q9WUD8
UniRef90:
UniRef90_Q9NVQ4
UniRef50:
UniRef50_Q9NVQ4
UniGene:
Mm.74605
CCDS:
CCDS23431.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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