| Type | Description |
|---|---|
| Definition | seizure related gene 6 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:15:00 | Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3. | 32567721 |
| 2019-01-19 10:46:00 | Results show that NPC1 loss-of-function in a mouse model of Niemann-Pick type C disease leads to enhanced cleavage of BACE1 substrates Sez6 and Sez6L, in addition to APP, and that this effect most likely involves altered trafficking of BACE1 and of its substrates within the endolysosomal system. Efficacy of Sez6 cleavage by BACE1 may be spatiotemporally differently regulated in contrast to the cleavage of Sez6L. | 29979789 |
| 2017-11-11 12:55:00 | study demonstrates that SEZ6 and SEZ6L are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF are suitable markers to monitor BACE1 inhibition in mice | 27716410 |
| 2015-08-29 11:35:00 | results indicate that N-glycosylation regulates cell morphology through modulating the cell surface distribution of sez-6 protein | 25960298 |
| 2013-10-26 12:38:00 | co-expression of sez-6 with motopsin restored the effect of motopsin at the basal level, while sez-6 expression alone showed no effects on cell morphology. Our results suggest that the interaction of motopsin and sez-6 modulates neuronal cell morphology | 23770366 |
| Type | IDs |
|---|---|
| Synonymous | BSRP-C, D11Bhm177e, sez-6 |
| Gene |
UniProtKB-ID:
SEZ6_MOUSE
UniprotKB:
Q7TSK2
UniParc:
UPI00001B4B11,
UPI000019280A,
UPI000047041C
EMBL:
AL845484,
BC053011,
D64009,
AL591065,
AK161576,
D29763,
AB206791,
BC055345,
D64010
Ensembl:
ENSMUSG00000000632
KO:
mmu:20370
|
| Nucleutide sequences |
EMBL-CDS:
AAH55345.1,
BAE44444.1,
BAA06167.1,
BAA10889.1,
AAH53011.1,
BAA10890.1,
BAE36472.1
Ensembl_TRS:
ENSMUST00000093995,
ENSMUST00000000646
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000091532,
ENSMUSP00000000646
RefSeq:
XP_036012371.1,
XP_006532700.1,
NP_001278154.1,
XP_030101583.1,
NP_067261.2,
XP_006532699.1,
XP_006532702.1,
XP_006532703.1
|
| Others |
UniRef100:
UniRef100_Q7TSK2
UniRef90:
UniRef90_Q7TSK2
UniRef50:
UniRef50_Q7TSK2
UniGene:
Mm.229330
CCDS:
CCDS25087.1,
CCDS70255.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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