| Type | Description |
|---|---|
| Definition | myristoylated alanine rich protein kinase C substrate |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 10:50:00 | While the presence of MARCKS does not affect whole brain levels of activated or total CDC42, authors propose that MARCKS is uniquely positioned to regulate CDC42 localization and interactions within specialized cellular compartments, such as nascent neurites. | 30185885 |
| 2019-02-23 11:30:00 | Study in mice reports that Marcks is regulated by acetylation through Tip60 and Sirt2. Maternal diabetes-induced MARCKS acetylation is required for its phosphorylation, which disables the protective effects of MARCKS on mitochondria and the endoplasmic reticulum, leading to cellular organelle stress and neural tube defect formation. | 30655546 |
| 2018-12-22 10:25:00 | this work establishes a novel role for MARCKS in axon dynamics and highlights the necessity of MARCKS as an organizer of DCC signaling at the membrane. | 29546593 |
| 2018-08-04 11:17:00 | Strongly support the existence of a regulatory module. | 29715315 |
| 2017-08-05 11:22:00 | ENaC activity is regulated by calpain-2 proteolysis of MARCKS. | 28468944 |
| Type | IDs |
|---|---|
| Synonymous | Macs, PKCSL |
| Gene |
UniProtKB-ID:
MARCS_MOUSE
UniprotKB:
P26645
UniParc:
UPI000000BA42
EMBL:
BC046601,
M60474
Ensembl:
ENSMUSG00000069662
KO:
mmu:17118
|
| Nucleutide sequences |
EMBL-CDS:
AAA39491.1,
AAH46601.1
Ensembl_TRS:
ENSMUST00000092584
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000090245
RefSeq:
NP_032564.1
|
| Others |
UniRef100:
UniRef100_P26645
UniRef90:
UniRef90_P30009
UniRef50:
UniRef50_P30009
UniGene:
Mm.30059
CCDS:
CCDS23784.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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