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56188 Fxyd1

56188

Fxyd1

FXYD domain-containing ion transport regulator 1

protein-coding

Mus musculus

基因描述

Type Description
Definition FXYD domain-containing ion transport regulator 1

研究结论

Date Results Publications
2020-08-13 17:13:00 Total FXYD1 subunit (modulates Na,K-ATPase activity) abundance was decreased in both mouse models 32293933
2019-09-28 10:59:00 Authors studied the male progeny of Fxyd1 null males bred to heterozygous Mecp2 female mice. Maximal NKA enzymatic activity was not altered by the loss of MeCP2, but it increased in mice lacking one Fxyd1 allele, suggesting that NKA activity is under Fxyd1 inhibitory control. 29902467
2017-12-23 11:48:00 It was proposed that FXYD1 plays a role in regulating AQP2 retention in apical membrane, and that this involves transfers between raft-like membrane domains in endosomes and plasma membranes. 29155857
2016-04-09 10:04:00 Both the extracellular PFXYD motif and the transmembrane domain of PLM but not the cytoplasmic tail were necessary for regulation of peak L-type Ca(2+) current amplitude. 25918050
2015-06-20 10:45:00 Decreased phosphorylation of PLM reduces Na/K pump activity and exacerbates Na overload, contractile dysfunction, and adverse remodelling following aortic constriction in mice. 25103111

名称对应

Type IDs
Synonymous 0610012C17Rik, 1110006M24Rik, Plm, Pml
Gene
UniProtKB-ID: PLM_MOUSE
UniprotKB: Q9Z239
UniParc: UPI00000019ED
EMBL: AF091390, BC024671, AK002585, AF089734
Ensembl: ENSMUSG00000036570
KO: mmu:56188
Nucleutide sequences
EMBL-CDS: AAH24671.1, AAD11781.1, AAD41683.1, BAB22208.1
Ensembl_TRS: ENSMUST00000206860, ENSMUST00000039909, ENSMUST00000205778, ENSMUST00000108110, ENSMUST00000205439, ENSMUST00000206474, ENSMUST00000206328, ENSMUST00000206012, ENSMUST00000071697, ENSMUST00000206305
Protein sequencees
Ensembl_PRO: ENSMUSP00000103745, ENSMUSP00000145818, ENSMUSP00000048460, ENSMUSP00000145589, ENSMUSP00000145920, ENSMUSP00000071617, ENSMUSP00000145712, ENSMUSP00000146288, ENSMUSP00000146064, ENSMUSP00000146295
RefSeq: XP_006540282.2, NP_062376.2, XP_011248954.1, NP_443717.1, XP_011248952.1, XP_011248950.1, XP_011248951.1, NP_919302.1, NP_443718.1, XP_030098669.1, XP_030098668.1, XP_011248953.1
Others
UniRef100: UniRef100_Q9Z239
UniRef90: UniRef90_Q9Z239
UniRef50: UniRef50_O00168
UniGene: Mm.1491
CCDS: CCDS21123.1

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