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15186 Hdc

15186

Hdc

histidine decarboxylase

protein-coding

Mus musculus

基因描述

Type Description
Definition histidine decarboxylase

研究结论

Date Results Publications
2020-10-24 14:04:00 Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling. 32054995
2020-03-14 11:36:00 Hdc mutant mice show abnormal behavior, striatal dopamine turnover and opioid peptide gene expression. 31216095
2019-04-13 10:15:00 Hdc(-/-) high-fat diet (HFD) mice had increased steatosis compared with WT HFD mice. WT HFD mice had increased biliary mass, biliary proliferation, senescence, fibrosis, and hepatic stellate cell activation, which were reduced in Hdc(-/-) HFD mice. In Hdc(-/-) HFD mice, serum leptin levels increased, whereas biliary Ob-R expression decreased. 29248461
2018-05-26 11:22:00 The results of this study indicated that Hdc deficiency in mice does not disturb the development of striatal and cortical interneurons and does not lead to the morphological and cytological phenotypes characterized by humans with Guilles de la Tourette syndrome. 28681514
2018-01-13 11:13:00 Genetic abnormalities in histaminergic signaling may produce a vulnerability to inflammatory challenge, setting the state for pathogenically dysregulated neuroimmune responses. 27381299

名称对应

Type IDs
Synonymous AW108189, Hdc-a, Hdc-c, Hdc-e, Hdc-s
Gene
UniProtKB-ID: DCHS_MOUSE
UniprotKB: P23738
UniParc: UPI0000022B9F
EMBL: CH466519, AK133455, AK088545, AF109137, AK150168, AK153104, S67000, AL844555, X57437
Ensembl: ENSMUSG00000027360
KO: mmu:15186
Nucleutide sequences
EMBL-CDS: BAE31724.1, AAB29093.1, BAE29356.1, EDL28158.1, AAC95389.1, BAE21666.1, CAA40685.1, BAC40415.1
Ensembl_TRS: ENSMUST00000028838
Protein sequencees
Ensembl_PRO: ENSMUSP00000028838
RefSeq: NP_032256.3, XP_006498847.1
Others
UniRef100: UniRef100_P23738
UniRef90: UniRef90_P23738
UniRef50: UniRef50_P19113
UniGene: Mm.18603
CCDS: CCDS16684.1

全选

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