Identification of 14-3-3epsilon substrates from embryonic murine brain.
[No authors listed]
摘要
Mice deficient in 14-3-3epsilon exhibit abnormal neuronal migration and die perinatally. We report here the first large-scale analysis of 14-3-3 interacting partners from primary animal tissue, identifying from embryonic murine brain 163 14-3-3epsilon interacting proteins and 85 phosphorylation sites on these proteins. Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and for maintaining USP8 in the cytosol.
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基因功能
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基因
Gm2076, Gm16374, Gm10358, Gm10290, Gapdh-ps14, Gm2308, Gm10293, Gm2445, Gm2451, Gm2467, Gm10313, Gm10566, Gm2546, Gm2574, Gm2606, Gm10284, Gm13292, Gm3200, Gm3222, Gm3272, Gm12537, Gm10327, Gm11953, Gm10291, Gm3534, Gm3608, Gapdh-ps15, Gm3671, Gm3695, Gm10359, Gm3809, Gm3839, Gm12033, Gm12286, Gm4217, Gm4335, Gm4366, Gm13882, Gm4462, Gm4575, Gm4609, Gm4654, Gm14148, Gm4691, Gm11560, Gm5121, Acly, Lars, Pacs1, Baiap2, Ogt, Ccdc88a, Cbr3, Erc1, Rims2, Slc25a5, Rplp0, Atp5a1, Atp5b, Cep131, Cacnb1, Capza1, Capza2, Capzb, Casp3, Ctnnd1, Cbl, Cbr1, Dbnl, Dclk1, Dcx, Ddx6, Dmwd, Dyrk1a, Eef1a1, Eef1a2, Mark2, Ewsr1, Igf2bp1, Sh3pxd2a, Srgap2, Gab2, Gapdh, Hnrnpab, Hspa8, Hsp90ab1, Hspa4, Irs1, Kif21b, Kif5a, Kif5b, Ksr1, Mark3, Map1b, Ncl, Nf1, Pik3r2, Cyth2, Flna, Pura, Gm11658, Exoc4, Wdr37, Dyrk1c, Frmd4a, Syn1, Syn2, Lrch2, Tbc1d4, Nav1, Rab3ip, Git1, Gm4804, Pacs2, Trim28, Ybx1, Ina, Ywhae, Ywhag, Ywhah, Mark1, Frmd4b, Mark4, Arhgap33, Fus, Sorbs2, Gm4929, Erc2, Rims3, Dlgap3, Srgap3, Git2, Psma1, Homer1, Homer3, Mprip, Rps3, Syn3, 3632413A11Rik, Fam188b, Edc3, Gm5138, Lmo7, Tbc1d22b, Brsk1, Crtc1, Gm5256, Gm5507, Gm5525, Gm5529, Gm5652, Gm5678, Gm5732, Ahi1, Nono, Caprin1, Actr1a, Gm5787, Gm5822, Cep170, Gm5863, Gm5869, Gm5920, Eef1b2, Srcin1, Dbn1, Gigyf1, Gm6170, Gm6192, Gm6283, Gm6316, Gm6392, Gm6540, Gm6548, Gm6627, Gm6681, Gm6767, Gm6789, Gm14165, Gm6944, Gm6946, Gm7105, Gm7129, Gm7183, Gm7286, Gm7293, Inpp5e, Tsc1, Gm12070, Gm7507, Gm7545, Gm7611, Gm7784, Gm11557, Gm8055, Mrip-ps, Gm8100, Gm8174, Gm8318, Gm8349, Slc25a5-ps, Gm14130, Gm8513, Gm8730, Gm8806, Gm8825, Gm12416, Gm9034, Gm9061, Gm9081, Rplp0-ps1, Gm9127, Gm9276, Tbc1d7, Eef1g, Gm9568, Dock7, Cltc, Gm9619, Gm9625, Gm15191, Wdr48, Gm16470, Borcs5, Trim32, Lrch3, Dclk2, Sfpq, R3hdm2, Lancl2, Vps9d1, Pgam5, Atat1, Pank2, Klc4, Rab11fip2, Brsk2, Dock8, Krt76, Tanc2, Nuak1, Msantd4, Ndel1, Usp8
原始数据
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文献解读
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