| Type | Description |
|---|---|
| Definition | ubiquitin specific peptidase 8 |
| Date | Results | Publications |
|---|---|---|
| 2019-04-20 10:49:00 | Deubiquitination of EPG5 by USP8 guards the autophagic flux in embryonic stem cells (ESCs) to maintain their stemness. This work uncovers a novel crosstalk pathway between ubiquitination and autophagy through USP8-EPG5 interaction to regulate the stemness of ESCs. | 30931944 |
| 2019-03-02 11:08:00 | USP8 interacted with transforming growth factorbetaactivated kinase1 (TAK1) and deubiquitinated the K63linked ubiquitination of TAK1. | 30221684 |
| 2018-12-22 10:28:00 | UBPy-sorted cargo to acrosome biogenesis and effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant, are reported. | 28299521 |
| 2016-02-06 12:21:00 | the membrane receptor MET, described herein for the first time in spermatids, is a USP8/UBPy-target substrate is delivered to the acrosome. | 25744385 |
| 2014-08-30 11:21:00 | in neuronal cells USP8 could be involved in endosomal trafficking, retrograde transport and synaptic plasticity. In disorders leading to neurodegeneration USP8 is upregulated and could influence the neuron-oligodendrocyte interactions. | 23615794 |
| Type | IDs |
|---|---|
| Synonymous | AI574262, AW557536, Ubpy, mKIAA0055 |
| Gene |
UniProtKB-ID:
UBP8_MOUSE,
A2AI52_MOUSE
UniprotKB:
Q80U87,
A2AI52
UniParc:
UPI0000022BA1,
UPI00004CB887
EMBL:
AK122195,
BC066126,
BC050947,
BC027052,
AL732330,
AF057146,
AB045709,
BC061465
Ensembl:
ENSMUSG00000027363
KO:
mmu:84092
|
| Nucleutide sequences |
EMBL-CDS:
BAB18534.1,
AAH50947.1,
BAC65477.1,
AAH66126.1,
AAD38869.1,
AAH61465.1,
AAH27052.1
Ensembl_TRS:
ENSMUST00000028841,
ENSMUST00000110416
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028841,
ENSMUSP00000106046
RefSeq:
NP_001239509.1,
XP_011238159.1,
NP_062703.2
|
| Others |
UniRef100:
UniRef100_Q80U87,
UniRef100_A2AI52
UniRef90:
UniRef90_Q80U87
UniRef50:
UniRef50_P40818-2
UniGene:
Mm.272629,
Mm.490069
CCDS:
CCDS16687.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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