| Type | Description |
|---|---|
| Definition | inositol polyphosphate-5-phosphatase E |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:22:00 | A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. | 32840212 |
| 2020-08-12 11:35:00 | Inpp5e attenuates Shh signaling in the neural tube through regulation of the relative timing of GliA and GliR production, which is important in understanding how the duration of Shh signaling regulates neural tube patterning. | 31964774 |
| 2018-12-22 11:35:00 | It postulates a three-step mechanism regulating ciliary localization of INPP5E, consisting of farnesylation- and PDE6delta-mediated targeting, INPP5E-PDE6delta complex diffusion into the cilium with transfer to the IFT system, and retention inside cilia. | 29140789 |
| 2018-09-15 11:08:00 | The expression levels of the INPP5E gene in NTD mouse embryos were significantly lower compared with control embryos, at the time of neural tube closure (gestational day 11.5). The INPP5E gene regulates the process of embryonic neural development. Abnormal levels of expression of the INPP5E gene may contribute to NTDs. | 29626185 |
| 2017-11-04 11:22:00 | Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT/GSK3beta signaling axis at cilia in SHH-dependent medulloblastoma that is regulated by INPP5E to maintain tumor cell cilia, promote SHH signaling and thereby medulloblastoma progression. | 28650469 |
| Type | IDs |
|---|---|
| Synonymous | 1200002L24Rik, 72kDa, mKIAA0123 |
| Gene |
UniProtKB-ID:
INP5E_MOUSE,
A2AIX0_MOUSE
UniprotKB:
Q9JII1,
A2AIX0
UniParc:
UPI0000022A52,
UPI0000D776E6
EMBL:
AK080075,
AK154097,
BC080295,
BC052717,
AK170786,
AL732541,
AF226683
Ensembl:
ENSMUSG00000026925
KO:
mmu:64436
|
| Nucleutide sequences |
EMBL-CDS:
BAE42028.1,
BAC37823.1,
AAH52717.1,
BAE32374.1,
AAF86957.1,
AAH80295.1
Ensembl_TRS:
ENSMUST00000145701,
ENSMUST00000114090
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000119485,
ENSMUSP00000109724
RefSeq:
NP_149125.1,
XP_036018337.1,
NP_001277366.1
|
| Others |
UniRef100:
UniRef100_A2AIX0,
UniRef100_Q9JII1
UniRef90:
UniRef90_Q9JII1
UniRef50:
UniRef50_Q9NRR6
UniGene:
Mm.330070
CCDS:
CCDS15805.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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