| Type | Description |
|---|---|
| Definition | ATP citrate lyase |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:27:00 | Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice. | 32888949 |
| 2020-03-21 11:03:00 | ACLY-3K acetylation also promotes ACLY protein stability in AML12 cells, a mouse hepatocyte cell line, and found that the deacetylase sirtuin 2 (SIRT2) deacetylates ACLY-3K and destabilizes ACLY in these cells. Mimicking ACLY-3K acetylation by replacing the three lysines with three glutamines (ACLY-3KQ variant) promoted lipid accumulation both in high glucose-treated AML12 cells and in the livers of high-fat diet. | 31197036 |
| 2019-11-02 12:50:00 | Study revealed increased kidney expression of RIPK3 in mouse models of progressive kidney fibrosis and in human chronic kidney disease kidney and demonstrate a pathway by which RIPK3 promotes fibrogenesis through the AKT-dependent activation of ATP citrate lyase independently of mixed-lineage kinase domain-like protein-dependent necroptosis. | 29415885 |
| 2018-07-28 12:19:00 | ACL regulates the net amount of acetyl groups available, leading to alterations in acetylation of H3(K9/14) and H3(K27) at the MYOD locus, thus increasing MYOD expression. | 29241530 |
| 2018-02-10 10:30:00 | We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner | 27582470 |
| Type | IDs |
|---|---|
| Synonymous | A730098H14Rik, AW538652 |
| Gene |
UniProtKB-ID:
ACLY_MOUSE,
Q3V117_MOUSE
UniprotKB:
Q91V92,
Q3V117
UniParc:
UPI000024D95E,
UPI00000290BE
EMBL:
AF332051,
AL590968,
BC056378,
AK132755,
BX842667,
AF332052
Ensembl:
ENSMUSG00000020917
KO:
mmu:104112
|
| Nucleutide sequences |
EMBL-CDS:
AAH56378.1,
AAK56080.1,
AAK56081.1,
BAE21336.1
Ensembl_TRS:
ENSMUST00000007131,
ENSMUST00000165111,
ENSMUST00000107389
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000127632,
ENSMUSP00000007131,
ENSMUSP00000103012
RefSeq:
XP_036012093.1,
NP_001186225.1,
NP_598798.1
|
| Others |
UniRef100:
UniRef100_Q91V92,
UniRef100_Q3V117
UniRef90:
UniRef90_P53396
UniRef50:
UniRef50_P53396
UniGene:
Mm.282039
CCDS:
CCDS25425.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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