| Type | Description |
|---|---|
| Definition | neurofibromin 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:20:00 | Brain-wide structural and functional disruption in mice with oligodendrocyte-specific Nf1 deletion is rescued by inhibition of nitric oxide synthase. | 32839340 |
| 2020-07-25 10:07:00 | demonstrate increased seizure susceptibility in a mouse model of NF1 and support the use of the Nf1(+/-) mouse for further investigations into the mechanistic link between NF1 and seizures | 31445228 |
| 2020-07-18 11:37:00 | Study in Nf1 knockout mice discovered that loss of Nf1 results in a dose-dependent decrease in Lhx6 expression, the transcription factor necessary to establish somatostatin- and parvalbumin-positive cortical GABAergic interneurons (CINs), which was rescued by the MEK inhibitor SL327, revealing a mechanism whereby a neurofibromin/Ras/MEK pathway regulates a critical CIN developmental milestone. | 32123116 |
| 2020-05-30 13:16:00 | the enriched expression of NF1 in inhibitory neurons may underlie inhibitory neuron-specific deficits in NF1. | 31234911 |
| 2019-12-07 10:31:00 | ZFP148 is important in the regulation of proliferation, smooth muscle gene downregulation, and apoptosis in aneurysm development. | 30580567 |
| Type | IDs |
|---|---|
| Synonymous | AW494271, Dsk9, E030030H24Rik, Mhdadsk9, Nf-1 |
| Gene |
UniProtKB-ID:
NF1_MOUSE
UniprotKB:
Q04690
UniParc:
UPI000002AEFC,
UPI000002AEFB,
UPI000002710A,
UPI000002AEFD
EMBL:
D30730,
D30731,
L10368,
L10369,
L10367,
X54924,
L10370
Ensembl:
ENSMUSG00000020716
KO:
mmu:18015
|
| Nucleutide sequences |
EMBL-CDS:
BAA06395.1,
BAA06396.1,
AAA39806.1,
CAA38690.1,
AAA68132.1
Ensembl_TRS:
ENSMUST00000071325,
ENSMUST00000108251
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000071289,
ENSMUSP00000103886
RefSeq:
XP_006532500.1,
XP_006532499.1,
XP_006532502.1,
XP_006532505.1,
XP_006532504.1,
XP_006532503.1,
NP_035027.1,
XP_030101504.1,
XP_006532501.1,
XP_036012293.1
|
| Others |
UniRef100:
UniRef100_Q04690
UniRef90:
UniRef90_Q04690
UniRef50:
UniRef50_P21359
UniGene:
Mm.255596,
Mm.488324
CCDS:
CCDS25119.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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