| Type | Description |
|---|---|
| Definition | TBC1 domain family, member 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:27:00 | The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Into Skeletal Muscle via Transporter SLC27A4/FATP4. | 32868338 |
| 2020-03-21 11:46:00 | These results provide genetic evidence linking signaling through TBC1D4 to enhanced muscle insulin sensitivity after activation of the cellular energy sensor AMPK. | 31175100 |
| 2018-09-22 10:37:00 | Fkbp5 knockouts are protected from high-fat diet-induced weight gain, show improved glucose tolerance and increased insulin signaling in skeletal muscle. We identify a novel association between FKBP51 and AS160, a substrate of AKT2 that is involved in glucose uptake. FKBP51 antagonism increases the phosphorylation of AS160. | 29170369 |
| 2017-06-10 10:59:00 | AS160 regulates glucose-independent eukaryotic cell proliferation through p21-dependent control of the cell cycle. | 27152871 |
| 2017-06-03 12:20:00 | Findings demonstrate that the RabGAP activity of AS160 maintains GLUT4 protein levels in a cell/tissue-autonomous manner and its inactivation causes lysosomal degradation of GLUT4 and postprandial hyperglycemia and hyperinsulinemia. | 27554475 |
| Type | IDs |
|---|---|
| Synonymous | 5930406J04Rik, A930035N22, AV295684, As160 |
| Gene |
UniProtKB-ID:
TBCD4_MOUSE,
E0CX53_MOUSE,
E9Q6Q8_MOUSE
UniprotKB:
Q8BYJ6,
E0CX53,
E9Q6Q8
UniParc:
UPI00006073D6,
UPI00001E93DB,
UPI0000DA6CDA,
UPI000051AE59,
UPI00006073DB,
UPI0000027BC9,
UPI0000DA6CDB
EMBL:
BC117870,
AK044719,
CT573019,
AK171689,
CT573033,
AK172575,
BC080762,
BC117869,
CT025630,
AK039337,
AK220347,
BC064433,
AK031120
Ensembl:
ENSMUSG00000033083
KO:
mmu:210789
|
| Nucleutide sequences |
EMBL-CDS:
AAH80762.1,
BAC32048.1,
AAI17871.1,
AAH64433.1,
BAC27263.1,
AAI17870.1,
BAE43074.1,
BAC30322.2,
BAE42613.1,
BAD90243.1
Ensembl_TRS:
ENSMUST00000162617,
ENSMUST00000161991
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000124909,
ENSMUSP00000125509
RefSeq:
NP_001074747.2,
XP_006518824.1,
XP_011243304.1,
XP_006518829.1,
XP_017171426.1,
XP_017171424.1,
XP_006518830.1,
XP_006518822.1,
XP_006518823.1,
XP_006518827.1,
XP_006518825.1,
XP_036014422.1,
XP_030103567.1,
XP_017171427.1,
XP_006518826.1
|
| Others |
UniRef100:
UniRef100_E9Q6Q8,
UniRef100_E0CX53,
UniRef100_Q8BYJ6
UniRef90:
UniRef90_E0CX53,
UniRef90_E9Q6Q8,
UniRef90_Q8BYJ6
UniRef50:
UniRef50_O60343-3,
UniRef50_M3WNN2
UniGene:
Mm.320639
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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