| Type | Description |
|---|---|
| Definition | phosphofurin acidic cluster sorting protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-01 11:46:00 | Insulin acutely regulates SIRT1 activity by triggering recruitment of PACS-2 and DBC1 to the SIRT1 N terminal region creating a regulatory hub. | 30415949 |
| 2018-01-20 12:06:00 | PACS-2 coordinates p53/p21- dependent cell cycle arrest with NF-kappaB/Bcl-xL-dependent pro-survival signaling to support DNA repair in response to genotoxic damage. | 26943323 |
| 2015-05-30 13:54:00 | CS-2 traffics to the nucleus where it regulates SIRT1-mediated p53 deacetylation. PACS-2 binds SIRT1 in vitro and directly inhibits SIRT1-catalyzed p53 deacetylation. | 25159152 |
| 2010-01-21 00:00:00 | PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system | 18296443 |
| 2010-01-21 00:00:00 | Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action. | 19481529 |
| Type | IDs |
|---|---|
| Synonymous | 6720425G15Rik, AW208651, AW489976, E230011J22, Pacs1l, mKIAA0602 |
| Gene |
UniProtKB-ID:
PACS2_MOUSE,
A0A1Y7VLZ7_MOUSE,
E9Q7E9_MOUSE
UniprotKB:
Q3V3Q7,
A0A1Y7VLZ7,
E9Q7E9
UniParc:
UPI0000606A83,
UPI00001E78E2,
UPI00001C4FBC
EMBL:
AK122326,
BC043302,
AK036581,
AC073562
Ensembl:
ENSMUSG00000021143
KO:
mmu:217893
|
| Nucleutide sequences |
EMBL-CDS:
AAH43302.1,
BAC65608.1,
BAE20504.1
Ensembl_TRS:
ENSMUST00000220541,
ENSMUST00000223502,
ENSMUST00000084891
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000152145,
ENSMUSP00000152439,
ENSMUSP00000081953
RefSeq:
XP_006515835.1,
XP_030102538.1,
XP_036013261.1,
XP_030102537.1,
XP_030102540.1,
XP_006515836.1,
XP_036013263.1,
XP_006515841.1,
NP_001074639.1,
NP_001278373.1,
XP_030102539.1,
XP_030102541.1,
XP_006515834.1,
XP_006515833.1,
XP_006515842.1,
XP_006515832.1,
XP_006515840.1,
XP_006515837.1,
NP_001278374.1
|
| Others |
UniRef100:
UniRef100_Q3V3Q7,
UniRef100_A0A1Y7VLZ7,
UniRef100_E9Q7E9
UniRef90:
UniRef90_Q3V3Q7,
UniRef90_E9Q7E9
UniRef50:
UniRef50_A0A3Q2U1S6,
UniRef50_Q86VP3-3
UniGene:
Mm.35754
CCDS:
CCDS88412.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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