| Type | Description |
|---|---|
| Definition | insulin receptor substrate 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:28:00 | Insulin receptor substrate-1 inhibits high-fat diet-induced obesity by browning of white adipose tissue through miR-503. | 32721050 |
| 2021-01-16 16:01:00 | Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics. | 33270683 |
| 2020-07-25 10:57:00 | Adipose tissue of high-fat fed mice displayed lower Atg16l1 mRNA expression and IRS1 protein content, and adipose tissue KLHL13 and CUL3 expression positively correlated to body mass index in humans. Authors propose that ATG16L1 deficiency evokes insulin resistance through induction of Klhl9 and Klhl13, which, in complex with Cul3, promote proteasomal IRS1 degradation. | 31515271 |
| 2020-03-28 10:29:00 | PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin. | 30770439 |
| 2019-10-12 10:57:00 | Our studies highlight that IRS-1, by regulating BMAL1, is an important regulator of Kir4.1 in Muller cells and the dysfunctional signaling mediated by IRS-1 may be detrimental to Kir4.1. | 31042800 |
| Type | IDs |
|---|---|
| Synonymous | G972R, IRS-1 |
| Gene |
UniProtKB-ID:
IRS1_MOUSE,
Q543V3_MOUSE
UniprotKB:
P35569,
Q543V3
UniParc:
UPI000000406D,
UPI00000282F4
EMBL:
AC137845,
AC123690,
AK045317,
X69722,
L24563,
AK142242
Ensembl:
ENSMUSG00000055980
KO:
mmu:16367
|
| Nucleutide sequences |
EMBL-CDS:
CAA49378.1,
AAA39335.1,
BAC32308.1,
BAE24991.1
Ensembl_TRS:
ENSMUST00000069799
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000063795
RefSeq:
NP_034700.2
|
| Others |
UniRef100:
UniRef100_P35569,
UniRef100_Q543V3
UniRef90:
UniRef90_P35570
UniRef50:
UniRef50_P35568
UniGene:
Mm.4952
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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