| Type | Description |
|---|---|
| Definition | regulating synaptic membrane exocytosis 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 10:46:00 | Here, the authors identify an essential role for the active zone protein RIM in stimulated somatodendritic dopamine release in the midbrain. In mice in which RIMs are selectively removed from dopamine neurons, action potentials failed to evoke significant somatodendritic release detected via D2 receptor-mediated currents. | 31486769 |
| 2017-07-15 10:43:00 | RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions. | 27537484 |
| 2017-06-10 10:17:00 | Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47. | 28377503 |
| 2016-01-02 11:04:00 | The function of RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly through direct or indirect modulation of the channel. | 26400943 |
| 2015-10-24 11:09:00 | RIM2alpha and RIM2beta promote a large complement of synaptic CaV1.3 Ca(2+) channels at inner hair cell presynaptic active zones and are required for normal hearing. | 26034270 |
| Type | IDs |
|---|---|
| Synonymous | 2810036I15Rik, AW048769, RIM2, Rab3ip2, Rim2(+40A), Rim2(+44A), Rim2(+4A), Serg2, Syt3-rs, mKIAA0751 |
| Gene |
UniProtKB-ID:
RIMS2_MOUSE,
D9HP81_MOUSE,
Q0VF51_MOUSE
UniprotKB:
Q9EQZ7,
D9HP81,
Q0VF51
UniParc:
UPI0000DBE495,
UPI00000256DB,
UPI00000275D3,
UPI00001C038C,
UPI0001DC1360
EMBL:
AK083172,
AC101886,
AC114537,
AC101935,
BC118979,
HM015529,
AB021131,
AK032619
Ensembl:
ENSMUSG00000037386
KO:
mmu:116838
|
| Nucleutide sequences |
EMBL-CDS:
BAC27953.1,
BAB18975.1,
BAC38794.1,
ADI78886.1,
AAI18980.1
Ensembl_TRS:
ENSMUST00000082054,
ENSMUST00000226410,
ENSMUST00000042917,
ENSMUST00000227243
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000080711,
ENSMUSP00000153868,
ENSMUSP00000048719,
ENSMUSP00000154153
RefSeq:
XP_030104146.1,
XP_017171892.1,
XP_030104155.1,
XP_036014974.1,
XP_017171876.1,
XP_036014978.1,
XP_017171860.1,
XP_036014980.1,
NP_001243313.1,
XP_030104161.1,
XP_036014979.1,
XP_017171859.1,
XP_030104147.1,
XP_017171893.1,
XP_017171898.1,
XP_017171894.1,
XP_017171901.1,
XP_036014973.1,
XP_036014976.1,
XP_030104157.1,
XP_017171878.1,
XP_017171861.1,
NP_001243312.1,
XP_030104153.1,
XP_017171862.1,
XP_017171863.1,
XP_030104158.1,
XP_030104159.1,
XP_017171869.1,
XP_017171889.1,
XP_017171865.1,
XP_017171874.1,
XP_036014975.1,
XP_017171873.1,
XP_017171886.1,
XP_006520406.1,
XP_030104160.1,
XP_036014981.1,
XP_030104152.1,
XP_036014982.1,
XP_030104154.1,
XP_036014972.1,
XP_017171896.1,
NP_001243311.1,
XP_017171899.1,
XP_036014983.1,
XP_030104145.1,
XP_017171890.1,
XP_017171864.1,
XP_030104156.1,
XP_036014977.1,
XP_017171888.1,
NP_444501.1
|
| Others |
UniRef100:
UniRef100_D9HP81,
UniRef100_Q0VF51,
UniRef100_Q9EQZ7
UniRef90:
UniRef90_Q0VF51,
UniRef90_D9HP81,
UniRef90_Q9EQZ7
UniRef50:
UniRef50_F1RCJ3,
UniRef50_D9HP81,
UniRef50_Q9EQZ7
UniGene:
Mm.309296
CCDS:
CCDS88756.1,
CCDS37067.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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