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A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking.

Nat. Struct. Mol. Biol.2010 Jul;17(7):901-8. Epub 2010 Jun 06
Pablo S Aguilar 1 , Florian Fröhlich , Michael Rehman , Mike Shales , Igor Ulitsky , Agustina Olivera-Couto , Hannes Braberg , Ron Shamir , Peter Walter , Matthias Mann , Christer S Ejsing , Nevan J Krogan , Tobias C Walther
Pablo S Aguilar 1 , Florian Fröhlich , Michael Rehman , Mike Shales , Igor Ulitsky , Agustina Olivera-Couto , Hannes Braberg , Ron Shamir , Peter Walter , Matthias Mann , Christer S Ejsing , Nevan J Krogan , Tobias C Walther
+ et al

[No authors listed]

Author information
  • 1 Institut Pasteur de Montevideo, Montevideo, Uruguay.

摘要


The plasma membrane delimits the cell and controls material and information exchange between itself and the environment. How different plasma-membrane processes are coordinated and how the relative abundance of plasma-membrane lipids and proteins is homeostatically maintained are not yet understood. Here, we used a quantitative genetic interaction map, or E-MAP, to functionally interrogate a set of approximately 400 genes involved in various aspects of plasma-membrane biology, including endocytosis, signaling, lipid metabolism and eisosome function. From this E-MAP, we derived a set of 57,799 individual interactions between genes functioning in these various processes. Using triplet genetic motif analysis, we identified a new component of the eisosome, Eis1, and linked the poorly characterized gene EMP70 to endocytic and eisosome function. Finally, we implicated Rom2, a GDP/GTP exchange factor for Rho1 and Rho2, in the regulation of sphingolipid metabolism.

基因


LSB5, RVS161, PMP1, SYP1, ELO2, PER1, ARE1, THR4, SSK22, ERS1, ABP1, CDC50, GIT1, ALR2, HAC1, HXT10, FAB1, ATG18, VPS13, ENT4, MMP1, YLL054C, AQY2, FPS1, SSK1, YEH2, RIC1, ERG3, RFU1, GAL2, EMP70, KIN2, HOG1, SRN2, NHA1, PEP3, VTA1, ENT2, THI7, LCB5, EXG1, MID2, FKS1, ARC18, ROM2, ELO3, VPS33, BLS1, CRN1, SST2, SNC1, DRS2, SYN8, GPB2, VPS8, ERP1, PRM9, SNF3, ARF1, BRE4, GCS1, ENT1, RGT2, GET3, OSH2, YDL012C, SES1, MRH1, IPT1, VPS41, DNF2, TMN2, KIN1, SAC6, ENT5, VPS64, AKR1, DPL1, SUR2, SWA2, CNL1, GGA1, SEM1, ATO3, RVS167, HKR1, SNX41, PKH3, PKH1, ITR1, SRO77, RTG3, SFT2, BOI1, ATG8, EDE1, FUI1, SLA1, CSG2, FAT1, QDR3, TAT1, ECM33, IST2, AIM3, CCZ1, CSH1, ARL1, FTH1, SDS24, RGD1, TSC10, APM3, PHO89, RTG2, COG1, SIP2, CHC1, XRN1, GPG1, SNF4, GUP1, KXD1, HNM1, PRM8, PIB2, GET1, ERG4, COG7, MTL1, GSC2, TWF1, PIL1, ASK10, SKN1, RSR1, CLC1, MVB12, CCH1, AZR1, YAP1802, YGR266W, YOR1, ASG7, CIS3, VPS35, LCB3, PBS2, LSB6, CHS6, BCK1, TOK1, PEP8, GYP6, BBC1, SYS1, GEF1, TOR1, JSN1, ENT3, DAL5, TOR2, PEX1, JEN1, SAC1, TPK3, MRP8, TGL1, MYO3, SMY1, BLI1, SFK1, ELM1, LAC1, CAP1, YPT52, BCH2, SPO14, YSR3, ENB1, PEX11, SMF1, SKM1, WSC3, ITR2, PKH2, ADH1, RTG1, INP54, PEX15, TAT2, YOL019W, TLG2, PLB3, SLG1, ROD1, AKR2, PEP12, WHI2, STD1, RSB1, VPS5, VPS21, ARF3, RAS1, INP53, VPS17, LCB4, MKK1, DGA1, HUA2, SNC2, SCP1, GPB1, BNR1, TPM2, SLM1, PRK1, SYG1, CAP2, INP51, FLO11, VPS9, TCB3, COG8, CMP2, SUR7, GSF2, ERG6, YPT7, HXT2, ERG5, EIS1, STV1, FET3, SEG1, AIP1, YPK2, MYO5, HFD1, EAR1, GYL1, ERG2, PEP5, HOR7, SCS7, BUL1, GOT1, PEX6, LEM3, CLA4, MON2, MSB3, MID1, WSC2, BOR1, ALP1, YNL208W, YNL194C, CHS1, MDG1, YCK2, INP52, RAS2, YPT53, TCB2, SNN1, END3, TPM1, MKS1, COG5, SLM2, COG6, SIW14, CRZ1, ARK1, VPS27, LRO1, ARE2, YNR048W, BIO5, AIF1, COS10, GYP5, APL5, TRE1, TGS1, YPL150W, MKK2, BEM3, ATG21, YDC1, BRO1, YTA6, PDR12, SUR1, ARL3, VPS16, PMA2, SVL3, RAD1, NCR1, LSP1, SRO7, BSP1, VPS4, ARN2, YHL044W, ARN1, WSC4, DUR3, LAG1, HSE1, VPS29, SLT2, IRE1, YPT35, GGA2, BZZ1, YCK1, YAP1801, SCH9, SKN7, SET5, SIT1, VMA3, VAC8, GIM4, MNN1, ISC1, GPA2, YPT31, TMN3, BOI2, SHO1, SCS2, YCK3, DDI1, FTR1, DNF1