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850513 HAC1

850513

HAC1

transcription factor HAC1

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition transcription factor HAC1

研究结论

Date Results Publications
2021-03-29 10:55:00 The consensus RNA structure of the Hac1 mRNA defines the unconventional splice sites and it is well conserved in Fungi and Metazoa 21593604
2020-12-12 13:23:00 Expression and function of an Hac1-regulated multi-copy xylanase gene in Saccharomyces cerevisiae. 32669586
2020-04-04 12:07:00 The authors show that phosphorylation of two different HAC1 splicing intermediates is required for their degradation by the 5'-->3' exonuclease Xrn1 to enact opposing effects on the UPR. We also found that ligated but 2'-phosphorylated HAC1 mRNA is cleaved, yielding a decay intermediate with both 5'- and 2'-phosphates at its 5'-end that inhibit 5'-->3' decay and suggesting that Ire1 degrades incompletely processed HAC1. 30874502
2019-07-06 11:18:00 Endoplasmic reticulum stress causes a diminished mRNA decay, thus resulting in the production of a population with an increased abundance of pre-HAC1 mRNA carrying an intact bipartite element, which facilitates its more efficient recruitment to Ire1p foci. 29165698
2017-10-21 11:14:00 Here, the authors show that a combination of inhibited translation initiation and accelerated protein degradation-both dependent on the intron-prevents the accumulation of Hac1 protein when the unfolded protein response is inactive. 27692069

名称对应

Type IDs
Synonymous ERN4, IRE15
Gene
UniProtKB-ID: HAC1_YEAST
UniprotKB: P41546
UniParc: UPI0000157F61, UPI0000157F60
EMBL: BK006940, D26506, D50617, D86413
EnsemblGenome: YFL031W
KO: sce:YFL031W
Nucleutide sequences
EMBL-CDS: BAA05513.1, DAA12409.1, BAA24425.1, BAA19565.1
EnsemblGenome_TRS: YFL031W_mRNA
Protein sequencees
EnsemblGenome_PRO: YFL031W
RefSeq: NP_116622.1
Others
UniRef100: UniRef100_P41546
UniRef90: UniRef90_P41546
UniRef50: UniRef50_P41546

全选

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研究热度

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