| Type | Description |
|---|---|
| Definition | 1-phosphatidylinositol-3-phosphate 5-kinase |
| Date | Results | Publications |
|---|---|---|
| 2018-08-18 11:44:00 | data suggest that Ivy1 modulates Fab1-mediated PI-3,5-P2 synthesis during membrane stress and may allow adjustment of the vacuole membrane environment. | 29674454 |
| 2017-09-16 11:52:00 | Pho85/CDK5 provides protection against hyperosmotic stress and acts before long-term adaptation provided by Hog1. This protection requires the vacuolar/endolysosomal signaling lipid PI3,5P2 We show that Pho85/CDK5 directly phosphorylates and positively regulates the PI3P-5 kinase Fab1/PIKfyve complex and provide evidence that this regulation is conserved in mammalian cells. | 28637746 |
| 2016-02-27 11:42:00 | ATG18 and FAB1 are involved in dehydration stress tolerance in Saccharomyces cerevisiae. | 25803831 |
| 2015-06-27 10:16:00 | Data suggest a model in which PtdIns(3)P 5-kinase protein Fab1/PIKfyve is dispensable to maintain vacuolar/lysosomal acidification. | 25713145 |
| 2013-07-20 11:20:00 | The crystal structure now unravels the presence of two distinct phosphoinositide-binding sites at the circumference of the seven bladed beta-propeller showing PtdINS3P and PtdIns(3,5)P2 proteins | 23069643 |
| Type | IDs |
|---|---|
| Synonymous | SVL7 |
| Gene |
UniProtKB-ID:
FAB1_YEAST
UniprotKB:
P34756
UniParc:
UPI000012A42C
EMBL:
BK006940,
D50617,
U01017
EnsemblGenome:
YFR019W
KO:
sce:YFR019W
|
| Nucleutide sequences |
EMBL-CDS:
BAA09258.1,
DAA12460.2,
AAA81360.1
EnsemblGenome_TRS:
YFR019W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YFR019W
RefSeq:
NP_116674.2
|
| Others |
UniRef100:
UniRef100_P34756
UniRef90:
UniRef90_P34756
UniRef50:
UniRef50_P34756
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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