| Type | Description |
|---|---|
| Definition | AAA family ATPase VPS4 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-07 10:16:00 | Data show that linear and cyclic versions of peptides bind to the S. cerevisiae AAA+ ATPase Vps4 (Vps4 ) with similar affinities | 31184588 |
| 2019-06-15 11:09:00 | we review recent advances in our understanding of the structures, activities, and mechanisms of the ESCRT-III and Vps4 machinery, including the first high-resolution structures of ESCRT-III filaments, the assembled Vps4 enzyme in complex with an ESCRT-III substrate, the discovery that ESCRT-III/Vps4 complexes can promote both inside-out and outside-in membrane fission reactions | 30095293 |
| 2019-02-16 12:04:00 | These observations directly verify long-standing predictions that ATP-hydrolyzing assemblies of ESCRT-III and Vps4 sever membranes. | 30573630 |
| 2018-07-07 11:58:00 | The authors now report a 3.2 A structure of Vps4 bound to an ESCRT-III peptide substrate. The new structure reveals that the peptide approximates a beta-strand conformation whose helical symmetry matches that of the five Vps4 subunits it contacts directly. | 29165244 |
| 2018-06-23 10:10:00 | The authors propose a model in which multiple Vps4 hexamers (four or more) draw together several ESCRT-III filaments. This process induces cargo crowding and inward membrane buckling, followed by constriction of the nascent bud neck and ultimately intraluminal vesicle generation by vesicle fission. | 29019322 |
| Type | IDs |
|---|---|
| Synonymous | CSC1, DID6, END13, GRD13, VPL4, VPT10 |
| Gene |
UniProtKB-ID:
VPS4_YEAST
UniprotKB:
P52917
UniParc:
UPI0000138D24
EMBL:
U25842,
X92680,
BK006949
EnsemblGenome:
YPR173C
KO:
sce:YPR173C
|
| Nucleutide sequences |
EMBL-CDS:
DAA11590.1,
AAB68107.1,
CAA63364.1
Gene_ORFName:
P9705.10
EnsemblGenome_TRS:
YPR173C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YPR173C
RefSeq:
NP_015499.1
|
| Others |
UniRef100:
UniRef100_P52917
UniRef90:
UniRef90_P52917
UniRef50:
UniRef50_P52917
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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