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856886 DDI1

856886

DDI1

Ddi1p

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition Ddi1p

研究结论

Date Results Publications
2021-03-20 13:26:00 New insights into the regulation of DNA-Protein Crosslink Repair by the Aspartic Protease Ddi1 in yeast. 32330640
2020-07-18 10:25:00 unlike other shuttling factors, Ddi1 and its homologs contain a conserved helical domain (helical domain of Ddi1, HDD) and a retroviral-like protease (RVP) domain. The RVP domain is probably responsible for cleavage of the precursor of the transcription factor Nrf1 in higher eukaryotes, which results in the up-regulation of proteasomal subunit genes. 32193351
2020-07-11 12:21:00 The Ddi1 protease contributes to DNA-protein crosslinks proteolysis. 31902667
2020-04-18 10:39:00 The yeast proteases Ddi1 and Wss1 are both involved in the DNA replication stress response. Double-deleted Deltaddi1, Deltawss1 yeast strain is hypersensitive to the replication drug hydroxyurea and this phenotype can be complemented only by catalytically competent Ddi1 protease. Key involvement of the helical domain preceding the Ddi1 protease domain is also shown. 31276951
2019-01-19 11:39:00 Data show that DNA-damage inducible protein 1 (Ddi1) cleavage is tightly regulated in vivo as it only takes place in yeast when calcium increases but under specific metabolic conditions. 29363267

名称对应

Type IDs
Synonymous VSM1
Gene
UniProtKB-ID: DDI1_YEAST
UniprotKB: P40087
UniParc: UPI000012909C
EMBL: U18917, AY692945, BK006939, U14002, AF034895
EnsemblGenome: YER143W
KO: sce:YER143W
Nucleutide sequences
EMBL-CDS: AAB64670.1, DAA07804.1, AAC18522.1, AAB82066.1, AAT92964.1
EnsemblGenome_TRS: YER143W_mRNA
Protein sequencees
EnsemblGenome_PRO: YER143W
RefSeq: NP_011070.3
Others
UniRef100: UniRef100_P40087
UniRef90: UniRef90_P40087
UniRef50: UniRef50_P40087

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