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Genome-wide association study of chronic periodontitis in a general German population.

J. Clin. Periodontol.2013 Nov;40(11):977-85. doi:10.1111/jcpe.12154. Epub 2013 Sep 11
Alexander Teumer 1 , Birte Holtfreter , Uwe Völker , Astrid Petersmann , Matthias Nauck , Reiner Biffar , Henry Völzke , Heyo K Kroemer , Peter Meisel , Georg Homuth , Thomas Kocher
Alexander Teumer 1 , Birte Holtfreter , Uwe Völker , Astrid Petersmann , Matthias Nauck , Reiner Biffar , Henry Völzke , Heyo K Kroemer , Peter Meisel , Georg Homuth , Thomas Kocher
+ et al

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Author information
  • 1 Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.

摘要


AIM:To identify loci associated with chronic periodontitis through a genome-wide association study (GWAS). MATERIALS AND METHODS:A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n = 3365 and SHIP-TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome-based autosomal and X-chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed. RESULTS:No genome-wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single SNP association reached genome-wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%. CONCLUSIONS:No single SNPs were found to be genome-wide significantly associated with chronic periodontitis in this study.

KEYWORDS: Study of Health in Pomerania, attachment loss, genome-wide association studies, periodontitis