| Type | Description |
|---|---|
| Definition | FSHD region gene 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 13:04:00 | Mutations in FRG1 and KMT2C were found to be associated with a younger age especially after correcting for tobacco smoking and sex in Chinese patients with lung adenocarcinoma. | 30821106 |
| 2019-08-17 10:50:00 | FRG1 expression is reduced in prostate adenocarcinoma tissue. FRG1 expression affects migration and invasion in AR negative prostate cancer cells through known MMPs and cytokines, which may be mediated primarily via p38 MAPK activation. | 30975102 |
| 2018-06-16 10:03:00 | Immunohistochemistry analysis showed reduced FRG1 levels in tumors which were supported by in silico analysis data. These findings suggest that reduction in FRG1 expression in gastric, colon and oral cavity tumor might have a role in tumor progression, by regulating cell migration and invasiveness. To elucidate a better understanding of molecular signaling involving FRG1 in angiogenesis regulation, further study is requir | 28947680 |
| 2016-01-23 10:19:00 | Penetrance of FSHD1 is low for largest alleles in the range of 9-10 RUs, and lower in women than men. | 25603992 |
| 2015-11-21 11:13:00 | Our results demonstrate that FRG1 is a direct DUX4 transcriptional target uncovering a novel regulatory circuit contributing to Facioscapulohumeral muscular dystrophy. | 25326393 |
| Type | IDs |
|---|---|
| Synonymous | FRG1A, FSG1 |
| Gene |
UniProtKB-ID:
FRG1_HUMAN
UniprotKB:
Q14331
UniParc:
UPI000012AC04
EMBL:
AK291890,
CH471056,
AF146191,
L76159,
BC053997
Ensembl:
ENSG00000275145,
ENSG00000283630,
ENSG00000109536,
ENSG00000283153
KO:
hsa:2483
|
| Nucleutide sequences |
EMBL-CDS:
EAX04600.1,
AAH53997.1,
AAD46768.1,
BAF84579.1,
AAA95939.1
Ensembl_TRS:
ENST00000636590,
ENST00000620886,
ENST00000637998,
ENST00000226798
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000490541,
ENSP00000226798,
ENSP00000489690,
ENSP00000483471
RefSeq:
NP_004468.1,
XP_016863447.1
|
| Others |
UniRef100:
UniRef100_Q14331
UniRef90:
UniRef90_Q14331
UniRef50:
UniRef50_Q14331
UniGene:
Hs.203772
CCDS:
CCDS34121.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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