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267012 DAOA

267012

DAOA

D-amino acid oxidase activator

protein-coding

Homo sapiens

基因描述

Type Description
Definition D-amino acid oxidase activator

研究结论

Date Results Publications
2020-10-31 13:14:00 pLG72 levels increase in early phase of Alzheimer's disease but decrease in late phase. 31520071
2019-03-30 10:15:00 The observed loss of SOD1 function in pLG72-expressing cells may explain the elevated levels and inhibition of U87 cell proliferation and has implications for understanding the onset of neurodegenerative diseases in humans. 30037290
2018-07-07 12:24:00 Findings showed that NOS1AP (rs348624, rs12742393 and rs1415263), DISC1 (rs821633 and rs1000731), DAOA (rs2391191) and GSK3B (rs6438552) SNPs had no association with development of early-onset schizophrenia; however, our finding suggested statistically significant role of the interaction of NOS1AP, DISC1, DAOA and GSK3B polymorphisms in schizophrenia susceptibility. 29100974
2018-01-13 11:17:00 In SNP-based single locus association analyses, the rs778292 in the DAOA gene showed significant association with schizophrenia. Additionally, a three-SNP haplotype (rs778292-rs3918342-rs1421292) in the DAOA gene were observed to be significantly associated with schizophrenia in a Taiwanese population. 28285246
2017-11-25 14:10:00 G72 transgenic mice have larger excitatory synapses with an increased amount of N-methyl-d-aspartate (NMDA) receptors in the molecular layer of dentate gyrus, compared with wild-type littermates. Transgenic animals have lower number of dentate granule cells with a parallel, but an even stronger decrease in the number of excitatory synapses in the molecular layer. 27163208

名称对应

Type IDs
Synonymous LG72, SG72
Gene
UniProtKB-ID: DAOA_HUMAN, A2T115_HUMAN, A0A024RDZ4_HUMAN
UniprotKB: P59103, A2T115, A0A024RDZ4
UniParc: UPI00001B01AA, UPI0000171C49, UPI0000F09CAB, UPI00000744B3, UPI0000001BB8
EMBL: DQ386870, AE014294, AY170469, DQ357223, DQ386869, DQ343761, AY138547, BC121091, AY223901, AL359751, CH471085, AY138546
Ensembl: ENSG00000182346
KO: hsa:267012
Nucleutide sequences
EMBL-CDS: AAO73604.1, AAN08433.1, ABC59904.1, EAX09080.1, AAO12727.1, AAN16027.1, AAN16028.1, AAN08432.1, ABC86111.1, AAI21092.1, ABD52721.1, ABD52720.1, EAX09081.1
Gene_ORFName: hCG_2036877
Ensembl_TRS: ENST00000618629, ENST00000559369, ENST00000600388, ENST00000329625, ENST00000473269, ENST00000375936, ENST00000595812
Protein sequencees
Ensembl_PRO: ENSP00000470244, ENSP00000453831, ENSP00000365103, ENSP00000329951, ENSP00000472260, ENSP00000483757, ENSP00000469539
RefSeq: NP_758958.3, NP_001155286.1, NP_001371574.1, NP_001371573.1, NP_001155284.1, NP_001371575.1
Others
UniRef100: UniRef100_A0A024RDZ4, UniRef100_A2T115, UniRef100_P59103
UniRef90: UniRef90_A0A024RDZ4, UniRef90_P59103, UniRef90_A2T115
UniRef50: UniRef50_A2T115, UniRef50_P59103, UniRef50_A0A024RDZ4
UniGene: Hs.381382
CCDS: CCDS53880.1, CCDS41905.1

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