| Type | Description |
|---|---|
| Definition | neuroligin 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:56:00 | Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action. | 31801062 |
| 2020-09-26 13:04:00 | Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering. | 31665629 |
| 2020-04-04 11:13:00 | we propose that this homozygous variant in NLGN1 can be the cause of the ASD/ID of these brothers although functional studies and/or model systems will be necessary to provide evidence for its pathogenicity. | 30460678 |
| 2017-11-26 00:05:00 | Findings support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD. | 27219346 |
| 2017-09-16 11:19:00 | We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD | 28841651 |
| Type | IDs |
|---|---|
| Synonymous | NL1 |
| Gene |
UniProtKB-ID:
NLGN1_HUMAN
UniprotKB:
Q8N2Q7
UniParc:
UPI0001C23308,
UPI0000072F54
EMBL:
AC008120,
AK074522,
BC032555,
AB028993,
GQ489206,
AC008082,
AC092923,
AC110871,
AC092967,
AC131158
Ensembl:
ENSG00000169760
KO:
hsa:22871
|
| Nucleutide sequences |
EMBL-CDS:
ADB12633.1,
AAH32555.1,
BAA83022.2,
BAC11039.1
Ensembl_TRS:
ENST00000457714,
ENST00000361589
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000354541,
ENSP00000392500
RefSeq:
XP_011510855.1,
NP_001352861.1,
NP_001352856.1,
XP_016861382.1,
XP_016861391.1,
XP_016861389.1,
XP_011510856.1,
XP_016861385.1,
NP_001352855.1,
NP_001352852.1,
NP_001352853.1,
NP_001352857.1,
NP_001352854.1,
XP_016861386.1,
XP_011510853.1,
NP_001352863.1,
NP_055747.1,
NP_001352859.1,
NP_001352858.1,
XP_005247294.1,
XP_016861377.1,
NP_001352862.1,
XP_016861383.1,
XP_016861384.1,
NP_001352860.1,
NP_001352864.1,
NP_001352865.1
|
| Others |
UniRef100:
UniRef100_Q8N2Q7
UniRef90:
UniRef90_Q62765
UniRef50:
UniRef50_Q62765
UniGene:
Hs.478289
CCDS:
CCDS3222.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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