| Type | Description |
|---|---|
| Definition | BLK proto-oncogene, Src family tyrosine kinase |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:11:00 | Polymorphisms of BLK are associated with renal disorder in patients with systemic lupus erythematosus. | 32313195 |
| 2019-12-28 11:37:00 | This is the first study showing an association of BLK rs2736340T/C and rs13277113A/G and BANK1 R61H with susceptibility to SLE in a Latin-American population. In addition, some BLK and BANK1 interactions were associated with susceptibility to SLE. | 31134304 |
| 2019-07-27 10:13:00 | The results suggest that this is the first study to disclose a possible association of genetic variants of BLK with susceptibility to GD, HT and AITD, and the diversity of AmiA levels. | 30589937 |
| 2019-06-08 12:54:00 | Study demonstrates the functional consequences of rare and low frequency missense variants in the interacting proteins BLK and BANK1, which are present alone, or in combination, in a substantial proportion of lupus patients. The rare variants found in patients, but not those found exclusively in controls, impair suppression of IRF5 and type-I IFN in human B cell lines. | 31101814 |
| 2018-06-09 11:20:00 | our results indicated that the BLK rs13277113 polymorphism was involved in the genetic background of RA in Chinese population and the association of BANK1 rs3733197 polymorphism with RA was dependent on the genotype of BLK rs13277113 polymorphism, highlighting B-cell response implicated in the pathogenesis of RA. | 28925718 |
| Type | IDs |
|---|---|
| Synonymous | MODY11 |
| Gene |
UniProtKB-ID:
BLK_HUMAN,
Q05D26_HUMAN,
E9PJX5_HUMAN
UniprotKB:
P51451,
Q05D26,
E9PJX5
UniParc:
UPI000006EA28,
UPI0000D497BB,
UPI0001F78498
EMBL:
AC022239,
CH471157,
BC007371,
S76617,
BC032413,
Z33998,
AF131216,
KF458689,
BC018703,
AK313751
Ensembl:
ENSG00000136573
KO:
hsa:640
|
| Nucleutide sequences |
EMBL-CDS:
EAW65617.1,
BAG36491.1,
AAH32413.1,
AAH07371.1,
AAB33265.1,
CAA83965.1,
AAH18703.1
Ensembl_TRS:
ENST00000259089,
ENST00000645242,
ENST00000529894
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000259089,
ENSP00000494690,
ENSP00000433663
RefSeq:
XP_011542129.1,
NP_001706.2,
XP_011542130.1,
XP_011542126.1,
XP_011542127.1,
XP_011542131.1,
NP_001317394.1
|
| Others |
UniRef100:
UniRef100_P51451,
UniRef100_Q05D26
UniRef90:
UniRef90_P51451
UniRef50:
UniRef50_P06239
UniGene:
Hs.146591
CCDS:
CCDS5982.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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