| Type | Description |
|---|---|
| Definition | integrin subunit alpha 8 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-04 10:05:00 | Integrin alpha8beta1 is the most fibroblast specific integrin and its contribution to fibrosis remains controversial. Recently, we demonstrated that alpha8beta1 plays a role in liver fibrosis in 4 different settings of mouse models; 3 with a neutralizing monoclonal antibody and one with Tam-inducible knockout mice. The mechanisms for the pro-fibrotic roles are through myofibroblast differentiation and TGF-beta activation. | 33433924 |
| 2017-02-18 10:22:00 | ITGA2B and ITGA8 have roles in prognosis in clear cell renal cell carcinoma patients | 26198048 |
| 2014-11-22 12:35:00 | In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. | 24700879 |
| 2014-04-05 10:56:00 | Mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease. | 24439109 |
| 2013-03-30 12:17:00 | the ITGA8 gene might have gender-specific roles in the development of schizophrenia. | 23153507 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ITA8_HUMAN,
B4DN28_HUMAN
UniprotKB:
P53708,
B4DN28
UniParc:
UPI00017A79C5,
UPI00001D80A0
EMBL:
EF444991,
AK297740,
CH471072,
AL590636,
AY371697,
AL359645,
L36531
Ensembl:
ENSG00000077943
KO:
hsa:8516
|
| Nucleutide sequences |
EMBL-CDS:
AAQ56848.2,
EAW86235.1,
AAA93514.1,
ACA06009.1,
BAG60090.1
Ensembl_TRS:
ENST00000378076
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000367316
RefSeq:
NP_003629.2,
XP_011518054.1,
NP_001278423.1
|
| Others |
UniRef100:
UniRef100_B4DN28,
UniRef100_P53708
UniRef90:
UniRef90_P53708,
UniRef90_A0A2K5PAS3
UniRef50:
UniRef50_P53708
UniGene:
Hs.171311
CCDS:
CCDS31155.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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