| Type | Description |
|---|---|
| Definition | defensin alpha 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 13:01:00 | Study in ApoE-/- transgenic mice expressing alpha-def-1 revealed that alpha-def-1 lowers total plasma cholesterol and decreases lesion size. However, lesion size was larger than in mice with total plasma cholesterol lowered to the same extent by inhibiting its adsorption or by ingesting a low-fat diet. alpha-def-1 levels correlated independently with lesion size in ApoE-/- mice. alpha-def-1 has competing effects on ath... | 32302327 |
| 2018-12-08 10:14:00 | lower DEFA1/DEFA3 copy number (CNV < 7) is associated with higher susceptibility to hospital-acquired infections (HAIs) in critically ill patients, indicating that host genetic factors are involved in the development of HAIs | 29950924 |
| 2018-11-10 11:15:00 | Human Neutrophil Peptide 1 directly binds and neutralizes Exotoxin A of Pseudomonas aeruginosa. | 29738776 |
| 2018-09-29 10:16:00 | Pretreatment of component b with human alpha-defensin-1 prior to addition of component a of Clostridium perfringens iota toxin prevented intoxication implicating that alpha-defensin-1 interacts with the toxin b component to prevent the formation of biologically active iota toxin on cells. | 29635426 |
| 2018-02-24 10:18:00 | DEFA1, DEFA3, and PPBP expression was significantly increased in hyperlipidemia and coronary heart disease patients compared with controls. | 28420383 |
| Type | IDs |
|---|---|
| Synonymous | DEF1, DEFA2, HNP-1, HP-1, HP1, MRS |
| Gene |
UniProtKB-ID:
DEF1_HUMAN
UniprotKB:
P59665
UniParc:
UPI0000129144
EMBL:
BC069423,
AF238378,
AF200455,
M26602,
BC112188,
M21130,
BC093791,
L12690,
X52053
Ensembl:
ENSG00000284983,
ENSG00000240247,
ENSG00000206047,
ENSG00000285176
KO:
hsa:1667,
hsa:728358
|
| Nucleutide sequences |
EMBL-CDS:
CAA36280.1,
AAH69423.1,
AAT68884.1,
AAT68875.1,
AAT68883.1,
AAA52302.1,
AAT68878.1,
AAH93791.1,
AAA52303.1,
AAT68880.1,
AAA36382.1,
AAT68879.1,
AAI12189.1
Ensembl_TRS:
ENST00000382689,
ENST00000382679,
ENST00000645146,
ENST00000644528,
ENST00000644617,
ENST00000644834,
ENST00000382692
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000493747,
ENSP00000496578,
ENSP00000496058,
ENSP00000496340,
ENSP00000372126,
ENSP00000372139,
ENSP00000372136
RefSeq:
XP_011533042.1,
NP_004075.1
|
| Others |
UniRef100:
UniRef100_P59665
UniRef90:
UniRef90_P59665
UniRef50:
UniRef50_P59665
UniGene:
Hs.380781
CCDS:
CCDS34797.1,
CCDS43691.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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