Characterization of the piRNA complex from rat testes.
[No authors listed]
摘要
Small noncoding RNAs regulate processes essential for cell growth and development, including mRNA degradation, translational repression, and transcriptional gene silencing (TGS). During a search for candidate mammalian factors for TGS, we purified a complex that contains small RNAs and Riwi, the rat homolog to human Piwi. The RNAs, frequently 29 to 30 nucleotides in length, are called Piwi-interacting RNAs (piRNAs), 94% of which map to 100 defined (< or = 101 kb) genomic regions. Within these regions, the piRNAs generally distribute across only one genomic strand or distribute on two strands but in a divergent, nonoverlapping manner. Preparations of piRNA complex (piRC) contain rRecQ1, which is homologous to qde-3 from Neurospora, a gene implicated in silencing pathways. Piwi has been genetically linked to TGS in flies, and slicer activity cofractionates with the purified complex. These results are consistent with a gene-silencing role for piRC in mammals.
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基因功能
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基因
Gm10505, Gm20204, Gm10619, Gm21221, Gm21269, Gm21284, Gm21388, Enkd1, LOC102632156, Gm30511, Gm14144, Gm30936, Gm31138, Gm31181, Gm32994, Gm33319, Gm11802, Gm33898, LOC102637737, Gm34856, Gm36617, Gm36877, Gm14244, Kdm3a, Ccdc117, Gm41109, Scrib, Unc119b, Mgat5, Prkab2, Rcc2, Abl2, Alas1, Ankfy1, Birc2, Cbl, Cbx5, Cebpg, Crkl, Cux1, Elk4, Pofut1, Usp15, Lancl1, Gml2, Mlc1, Glmn, Mcl1, Nfatc3, Pafah1b2, Npepps, Rad51d, Rps15, Shc1, Spin1, Strbp, Aph1b, Stxbp4, Tmem194, Lcor, Kctd7, Gabpb2, Nudt15, Slc43a2, Dnajc27, Wdr41, Hmbox1, Dedd, Nr2c2, Tgoln1, Tub, Tuba3b, Zbtb10, Otud7b, Gba2, Crebl2, Ddx19b, Cdk10, Map2k5, Mgll, Ago2, Sec31b, Dcaf10, Sbno1, Rpgrip1l, Arhgap20, Zc3h12c, Ccdc15, Fktn, Clcn6, Gins2, Dnajb9, Tbl2, Ip6k1, Tacc1, C530008M17Rik, Kctd10, 9330102E08Rik, Zc3h4, Zdhhc23, Rc3h1, Rbm33, Zyg11b, D6Ertd474e, Usp2, Nfat5, Gm5878, Nagk, Rbm14, Rangrf, Rad18, Rad54b, Gm6567, Zfp280b, Asb1, Lima1, Commd4, Inip, Med7, Wdr61, Borcs7, 4933404O12Rik, Gid4, Smim7, Lman2, 1700020N18Rik, Gatad1, Ccar1, 4930465K10Rik, Cep83os, Derl1, 0610030E20Rik, Nufip2, Cgrrf1, 1700001L05Rik, 1700008K24Rik, Mrps9, Vkorc1l1, Ipmk, Tbccd1, 4933440M02Rik, 1700006A11Rik, Phf7, 1810055G02Rik, Wdfy3, Ndc1, 1700042G15Rik, 1700029M20Rik, 4930444F02Rik, 4921525O09Rik, 1700009C05Rik, 1700016C19Rik, 4930481A15Rik, Kmt2b, Pcgf5, Usp31, Dtl, Spopl, Arfgap2, 4931408D14Rik, Tmem50b, Polh, Rad54l2, Gtf2a1, Peli2, Cmtm4, Golga2, LOC100910343, LOC100910620, LOC100911370, LOC100912214, LOC102546709, LOC102548041, LOC102548125, LOC102548278, LOC102549247, LOC102549328, LOC102553877, LOC102554796, LOC102555822, LOC103690246, LOC103691516, Cep83os, Pabpc1, Gmpr2, Donson, Tmem9b, RGD1306519, Mrpl51, RGD1309748, Zranb3, Fam20b, Tacc1, Fam53b, Otud7b, Trim14, Mtmr2, Paqr8, Asb1, Mlx, Serpinb6b, Alkbh8, Ccdc117, Tsnaxip1, Golga2, LOC691658, Myh10
原始数据
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文献解读
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