| Type | Description |
|---|---|
| Definition | WD repeat and FYVE domain containing 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 10:52:00 | Although the heterozygous depletion of the autophagy adaptor protein Alfy/Wdfy3 has no consequence in control mice, it significantly accelerates age of onset and progression of Huntington's disease pathogenesis. Alfy depletion in mice accelerates the aberrant accumulation of this pathological hallmark shared across adult-onset neurodegenerative diseases. | 31899071 |
| 2020-06-20 10:24:00 | Wdfy3 plays an essential role in cardiac development, which may be mediated by modulation of Notch1 signalling. | 30428088 |
| 2019-10-19 11:34:00 | These findings support a critical role for Wdfy3 in mitochondrial homeostasis with implications for neuron differentiation, neurodevelopment and age-dependent neurodegeneration. | 30054502 |
| 2017-12-30 11:08:00 | Data provide a novel association between WDFY3 and the RANKL-induced osteoclastogenesis pathway via the modulation of TRAF6. | 27330028 |
| 2017-12-16 11:32:00 | The authors report that this evolutionarily conserved protein is required for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. | 27648578 |
| Type | IDs |
|---|---|
| Synonymous | 2610509D04Rik, ALFY, AW319683, B930017C24, BWF1, Bchs, D5Ertd66e, Ggtb3, ZFYVE25, mKIAA0993 |
| Gene |
UniProtKB-ID:
WDFY3_MOUSE,
G3UYW1_MOUSE,
A0A1D5RLV7_MOUSE
UniprotKB:
Q6VNB8,
G3UYW1,
A0A1D5RLV7
UniParc:
UPI0000225AF8,
UPI000035700E,
UPI0003D75967,
UPI00001F326A
EMBL:
AC158143,
AY336569,
AC171108,
AK047077,
AC171109,
AC131915
Ensembl:
ENSMUSG00000043940
KO:
mmu:72145
|
| Nucleutide sequences |
EMBL-CDS:
AAQ84516.1,
BAC32952.1
Ensembl_TRS:
ENSMUST00000053177,
ENSMUST00000174698,
ENSMUST00000174598,
ENSMUST00000212024
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000052607,
ENSMUSP00000134541,
ENSMUSP00000134244,
ENSMUSP00000148521
RefSeq:
XP_006535287.1,
XP_006535290.1,
XP_036021402.1,
XP_030110680.1,
XP_030110681.1,
XP_006535286.1,
XP_006535283.1,
XP_006535284.1,
NP_766470.2,
XP_036021401.1,
XP_006535288.1,
XP_006535289.1,
XP_006535285.1,
XP_006535291.1
|
| Others |
UniRef100:
UniRef100_Q6VNB8,
UniRef100_G3UYW1,
UniRef100_A0A1D5RLV7
UniRef90:
UniRef90_A0A3Q2HTN6,
UniRef90_Q6VNB8
UniRef50:
UniRef50_Q8IZQ1-2,
UniRef50_A0A5F4CY99
UniGene:
Mm.332522,
Mm.447999
CCDS:
CCDS19473.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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