| Type | Description |
|---|---|
| Definition | Der1-like domain family, member 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:15:00 | Estrogen treatment decreased alpha-ENaC expression but increased derlin-1 expression in mouse renal collecting duct (mpkCCDc14) cells. | 31113930 |
| 2017-08-12 11:13:00 | The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells. | 28137758 |
| 2014-01-25 11:11:00 | Cav-1 may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation. | 24089527 |
| 2012-11-17 10:24:00 | Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice | 22479592 |
| 2011-12-31 12:32:00 | Derlin-1 regulates the turnover of superoxide dismutase 1 by promoting the proteasomal and autophagosomal degradation of SOD1 protein, but not by decreasing mutant SOD1 mRNA levels. | 21185345 |
| Type | IDs |
|---|---|
| Synonymous | 1110021N07Rik, AI195141, AW551338, Derlin-1 |
| Gene |
UniProtKB-ID:
DERL1_MOUSE
UniprotKB:
Q99J56
UniParc:
UPI0000021EB2
EMBL:
AK152901,
AK075631,
AK007435,
BC085490,
AK043420,
AK152197,
BC003454
Ensembl:
ENSMUSG00000022365
KO:
mmu:67819
|
| Nucleutide sequences |
EMBL-CDS:
BAC35868.1,
BAE31026.1,
BAB25036.1,
BAE31582.1,
AAH85490.1,
BAC31545.1,
AAH03454.1
Ensembl_TRS:
ENSMUST00000022993
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022993
RefSeq:
NP_077169.1
|
| Others |
UniRef100:
UniRef100_Q99J56
UniRef90:
UniRef90_Q9BUN8
UniRef50:
UniRef50_Q9BUN8
UniGene:
Mm.289387,
Mm.444431
CCDS:
CCDS27484.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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