| Type | Description |
|---|---|
| Definition | inositol polyphosphate multikinase |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:17:00 | Inositol polyphosphate multikinase in adipocytes is dispensable for regulating energy metabolism and whole body metabolic homeostasis. | 32634320 |
| 2020-06-06 13:34:00 | Deletion of IPMK in cell lines and intact mice virtually abolishes lipophagy, promotes liver damage as well as inflammation, and impairs hepatocyte regeneration. | 30840891 |
| 2020-05-30 13:12:00 | These results suggest a physiological role for IPMK in regulating expression of Syt2. | 31221192 |
| 2020-04-11 12:29:00 | Study utilized B cell-specific inositol polyphosphate multikinase (IPMK)-deficient mice to investigate the role of higher order inositol phosphates (InsP6) in B cell immunity and showed that IPMK is a regulator of T cell-independent immune responses and that InsP6 confers a mechanism to regulate the activity of Bruton's tyrosine kinase (Btk) in B cell receptor signaling. | 31189594 |
| 2019-07-06 11:14:00 | IP5 promotes HIF-1alpha prolyl hydroxylation and pVHL-dependent degradation of HIF-1alpha. IPMK deletion in mouse brain increases HIF-1alpha/VEGF levels and vascularization. This disrupts blood-brain barrier and enhances brain blood vessel permeability. IPMK, via its product IP5, negatively regulates angiogenesis by inhibiting VEGF expression. IP5 acts by enhancing HIF-1alpha hydroxylation and thus pVHL-dependent degra... | 29279301 |
| Type | IDs |
|---|---|
| Synonymous | 2410017C19Rik, AA408208, Impk |
| Gene |
UniProtKB-ID:
IPMK_MOUSE,
D3YWA2_MOUSE
UniprotKB:
Q7TT16,
D3YWA2
UniParc:
UPI00000261F2,
UPI0000429123,
UPI000019B063
EMBL:
AC156270,
BC052463,
AK036084,
AK036978,
AK010523
Ensembl:
ENSMUSG00000060733
KO:
mmu:69718
|
| Nucleutide sequences |
EMBL-CDS:
AAH52463.1,
BAC29300.1,
BAB27004.1,
BAC29655.1
Ensembl_TRS:
ENSMUST00000079252,
ENSMUST00000118381,
ENSMUST00000147277,
ENSMUST00000121446
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000078240,
ENSMUSP00000120073,
ENSMUSP00000113083,
ENSMUSP00000112568
RefSeq:
NP_001334120.1,
XP_011241857.1,
NP_081460.1
|
| Others |
UniRef100:
UniRef100_D3YWA2,
UniRef100_Q7TT16
UniRef90:
UniRef90_Q7TT16
UniRef50:
UniRef50_Q7TT16
UniGene:
Mm.245867
CCDS:
CCDS23918.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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