| Type | Description |
|---|---|
| Definition | ubiquitin specific peptidase 15 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 12:58:00 | Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells. | 31933062 |
| 2020-11-21 13:27:00 | USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. | 32839293 |
| 2020-07-04 10:53:00 | Deficiency in macrophages protects mice against lipopolysaccharide-induced septic shock, and knockdown of Usp15 in Hrd1-knockout macrophages restores the reduced IL-6 production. | 31477895 |
| 2019-06-08 11:12:00 | USP15 inhibited multiple myeloma cell apoptosis through activating a feedback loop with NF-kappaBp65. USP15 silencing inhibited multiple myeloma tumor growth. | 30459344 |
| 2019-04-13 11:58:00 | Study reports that USP15 affects cancer cell response to inhibitors by regulating homologous recombination repair. USP15 is recruited to DNA double-strand breaks (DSBs) by MDC1. USP15 deubiquitinates BARD1 BRCT domain, and promotes BARD1-HP1gamma interaction, resulting in BRCA1/BARD1 retention at DSBs. Cancer-associated USP15 mutations, with decreased USP15-BARD1 interaction, increases Pduanyu37 inhibitor sensitivity. | 30874560 |
| Type | IDs |
|---|---|
| Synonymous | 4921514G19Rik, AI327321, E430033I05Rik, Gcap18 |
| Gene |
UniProtKB-ID:
UBP15_MOUSE,
Q3TSV9_MOUSE
UniprotKB:
Q8R5H1,
Q3TSV9
UniParc:
UPI00000288BC,
UPI000024DA86,
UPI000002B67E,
UPI000002182E,
UPI000002B67F,
UPI00005B1DA6
EMBL:
AK161771,
AK122301,
AK168755,
BC050042,
AK133852,
AF468037,
AK083303,
AK145749,
AK161469,
CH466578,
AK046332
Ensembl:
ENSMUSG00000020124
KO:
mmu:14479
|
| Nucleutide sequences |
EMBL-CDS:
AAH50042.1,
BAE21887.1,
BAE40593.1,
BAC32683.1,
BAC65583.1,
BAE36413.1,
AAL77418.1,
EDL24441.1,
BAC38854.1,
BAE26626.1,
BAE36566.1
Ensembl_TRS:
ENSMUST00000220377,
ENSMUST00000020334
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000151244,
ENSMUSP00000020334
RefSeq:
NP_081880.2,
XP_006513288.1,
XP_036011509.1,
XP_006513289.1,
NP_001288557.1,
XP_006513290.1,
XP_006513291.1,
XP_036011508.1
|
| Others |
UniRef100:
UniRef100_Q8R5H1,
UniRef100_Q3TSV9
UniRef90:
UniRef90_Q9Y4E8,
UniRef90_Q3TSV9
UniRef50:
UniRef50_Q3TSV9,
UniRef50_Q9Y4E8
UniGene:
Mm.244209,
Mm.470032
CCDS:
CCDS24217.1,
CCDS88095.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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