| Type | Description |
|---|---|
| Definition | aminolevulinic acid synthase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:51:00 | Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver. | 33307066 |
| 2014-09-06 12:22:00 | silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice. | 24821812 |
| 2012-04-14 11:49:00 | Both ALAS1 mRNA and protein content were induced in diabetic animals, accompanied by decreased Akt phosphorylation and increased nuclear FOXO1, PGC-1alpha and FOXO1-PGC-1alpha complex levels. | 22070747 |
| 2011-08-27 11:18:00 | active site functional asymmetry extends to chimeric ALAS/AONS proteins, which while having a different oligomeric state, exhibit different rates of product release from the two ALAS and two AONS active sites due to the created intermolecular strain | 21600186 |
| 2011-02-26 11:36:00 | Egr-1 regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme | 21044876 |
| Type | IDs |
|---|---|
| Synonymous | ALAS, ALAS-N, Alas-1, Alas-h |
| Gene |
UniProtKB-ID:
HEM1_MOUSE,
Q3V0B2_MOUSE
UniprotKB:
Q8VC19,
Q3V0B2
UniParc:
UPI000024E04C
EMBL:
M63245,
BC022110,
AK133283
Ensembl:
ENSMUSG00000032786
KO:
mmu:11655
|
| Nucleutide sequences |
EMBL-CDS:
AAA91867.1,
AAH22110.1,
BAE21592.1
Ensembl_TRS:
ENSMUST00000141118,
ENSMUST00000112524
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000117014,
ENSMUSP00000108143
RefSeq:
NP_065584.2,
NP_001278764.1
|
| Others |
UniRef100:
UniRef100_Q8VC19
UniRef90:
UniRef90_P13195
UniRef50:
UniRef50_P22557
UniGene:
Mm.290578
CCDS:
CCDS40756.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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