| Type | Description |
|---|---|
| Definition | cut-like homeobox 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 11:01:00 | To determine the role for CUX1 in hematopoiesis, this study generated 2 short hairpin RNA-based mouse models with approximately 54% (Cux1(mid)) or approximately 12% (Cux1(low)) residual CUX1 protein. Cux1(mid) mice develop myelodysplastic syndrome (MDS) with anemia and trilineage dysplasia, whereas CUX1(low) mice developed MDS/myeloproliferative neoplasms and anemia. | 29592892 |
| 2018-02-10 10:40:00 | reduction of VAV2 in absence of CUX1 was associated with a significant decrease of RAC1 activity in response to epithelial wounding. Our results identify a novel pathway by which CUX1 regulates normal intestinal epithelial cell restitution | 28893557 |
| 2017-10-21 12:19:00 | Cux1 expression in polycystic kidney disease is not directly involved in cystogenesis but promotes cell proliferation required for expansion of existing cysts, primarily by repression of p27. | 28701314 |
| 2016-07-02 11:30:00 | Cux1 is essential for the developmental modulation of intrinsic excitability and the switch to a Kv1-dependent firing mode necessary for interhemispheric innervation. | 26804994 |
| 2016-01-16 11:43:00 | Findings reinforce the link between oxidative DNA damage and cellular senescence and suggest that the role of CUX1 as an accessory factor in DNA repair will be critical in physiological situations that generate higher levels of reactive oxygen species. | 25682875 |
| Type | IDs |
|---|---|
| Synonymous | CDP, Cutl1, Cux, Cux-1 |
| Gene |
UniProtKB-ID:
CUX1_MOUSE,
H3BK24_MOUSE,
Q5BL05_MOUSE,
Q9JJB6_MOUSE,
Q6AXG1_MOUSE,
H3BJN3_MOUSE,
H3BLS0_MOUSE,
H3BKT0_MOUSE,
E9QKE9_MOUSE
UniprotKB:
P53564,
H3BK24,
Q5BL05,
Q9JJB6,
Q6AXG1,
H3BJN3,
H3BLS0,
H3BKT0,
E9QKE9
UniParc:
UPI0000356E4C,
UPI00000287BB,
UPI00005B2E7D,
UPI00015DF1CB,
UPI00005B2E7B,
UPI00024676EA,
UPI00005B2E22,
UPI0000402843,
UPI0000D62C22,
UPI00005643C9,
UPI00005B2E7C,
UPI000016D0E8,
UPI00004EA719
EMBL:
AC080158,
BC079570,
X75013,
AB041595,
U46683,
U46684,
AC083890,
AY037807,
BC090847,
AF004225,
AC087329,
AK220173
Ensembl:
ENSMUSG00000029705
KO:
mmu:13047
|
| Nucleutide sequences |
EMBL-CDS:
AAD12485.1,
CAA52922.1,
BAD90358.1,
AAB41146.1,
AAC52775.1,
AAK59986.1,
AAH90847.1,
BAA95078.1,
AAH79570.1
Ensembl_TRS:
ENSMUST00000175975,
ENSMUST00000176216,
ENSMUST00000176778,
ENSMUST00000176745,
ENSMUST00000004097
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000135223,
ENSMUSP00000135054,
ENSMUSP00000135892,
ENSMUSP00000135512,
ENSMUSP00000004097
RefSeq:
XP_006504419.1,
XP_006504413.1,
XP_006504417.1,
NP_034116.3,
XP_030109966.1,
XP_006504415.1,
XP_030109975.1,
XP_017176143.1,
XP_030109972.1,
NP_001278169.1,
NP_941004.2,
NP_001278168.1,
XP_036020666.1,
XP_030109973.1,
XP_030109974.1,
XP_030109967.1,
NP_001278167.1,
XP_030109968.1,
NP_001278163.1,
NP_001278162.1,
XP_030109970.1,
XP_030109969.1
|
| Others |
UniRef100:
UniRef100_H3BK24,
UniRef100_H3BLS0,
UniRef100_E9QKE9,
UniRef100_Q9JJB6,
UniRef100_H3BJN3,
UniRef100_Q5BL05,
UniRef100_P53564,
UniRef100_H3BKT0,
UniRef100_Q6AXG1
UniRef90:
UniRef90_P53564,
UniRef90_P70403
UniRef50:
UniRef50_P70403,
UniRef50_P53564
UniGene:
Mm.320317
CCDS:
CCDS71684.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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