Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector.
[No authors listed]
摘要
With the widespread appearance of antibiotic-resistant bacteria, there is an increasing demand for novel strategies to control infectious diseases. Furthermore, it has become apparent that the bacterial life style also contributes significantly to this problem. Bacteria living in the biofilm mode of growth tolerate conventional antimicrobial treatments. The discovery that many bacteria use quorum-sensing (QS) systems to coordinate virulence and biofilm development has pointed out a new, promising target for antimicrobial drugs. We constructed a collection of screening systems, QS inhibitor (QSI) selectors, which enabled us to identify a number of novel QSIs among natural and synthetic compound libraries. The two most active were garlic extract and 4-nitro-pyridine-N-oxide (4-NPO). GeneChip-based transcriptome analysis revealed that garlic extract and 4-NPO had specificity for QS-controlled virulence genes in Pseudomonas aeruginosa. These two QSIs also significantly reduced P. aeruginosa biofilm tolerance to tobramycin treatment as well as virulence in a Caenorhabditis elegans pathogenesis model.
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基因功能
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基因
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clpV1, PA1141, PA1819, PA0483, accB, accC, PA1657, PA2407, rubA2, rubA1, proS, PA1328, PA1369, fusA2, pscI, pscB, PA4844, dipZ, PA2266, PA1597, PA0089, PA5205, argE, PA0471, PA0194, PA5266, hcpB, PA2222, PA2410, PA0496, PA2406, PA2383, PA2384, PA0255, PA5543, PA5544, PA5545, PA2299, PA1658, PA4838, speA, PA0094, desA, PA4883, PA4884, PA2293, PA5116, typA, PA3676, PA3677, PA4562, rpsT, fimU, pilV, PA0384, ruvA, PA1160, greB, PA2860, PA1114, PA3446, PA3447, PA2188, flgC, bioF, argB, PA5324, PA1647, PA0200, PA1879, dnaB, rplI, PA1075, mdoH, PA5078, PA4841, PA4842, PA4843, gpuP, pscF, algZ, argH, PA2408, PA2409, PA0480, PA2101, PA5347, PA5348, PA5349, PA2122, PA0492, PA1736, PA5248, PA5249, PA5250, PA1046, msuD, PA1068, PA5305, PA5306, PA5431, PA5432, PA3576, PA3577, PA1217, PA3896, PA3897, PA5233, PA5234, PA0587, PA2375, PA2376, PA0490, PA2092, lytB, tatB, tatC, PA1362, PA0149, PA0285, PA5210, PA5211, PA0252, PA2091, prtR, PA0648, PA1366, PA2209, PA1650, PA0921, PA2575, PA2576, PA2287, PA0886, PA0877, PA5519, PA5520, PA5521, PA2378, PA4927, PA4928, PA4923, PA4924, PA0284, ppk, hemB, thiC, PA4974, pslG, PA4874, osmE, PA0681, phhA, PA3458, PA3459, exsA, PA2224, PA2311, PA1220, PA0244, pslA, PA1735, algQ, dsbH, PA0879, PA5257, PA5258, hemD, PA4914, PA4915, gpuR, PA2230, PA2251, aguA, PA0383, acsA, PA2269, PA4908, PA4909, PA5465, PA5466, PA5467, PA1957, PA1938, parC, PA4965, ubiE, PA5064, PA2083, PA1788, PA4897, opdK, PA4899, pvdD, PA3762, purL, PA2411, ambC, pscR, aspP, PA4972, PA2270, PA0653, PA0206, PA0481, nirL, PA1697, PA5075, PA5076, PA2295, PA1387, PA3670, PA3671, PA0731, PA1755, PA2169, PA3674, PA3675, PA4863, ureD, PA4115, bphO, PA2271, narG, narK2, narJ, narH, PA3856, pcs, moaA1, micA, PA3024, PA3025, PA3523, gloA1, PA4066, oprG, PA3866, PA3867, PA3411, PA3412, PA2971, PA2972, PA3858, PA3859, thiG, PA3860, rhl, dauB, dauA, PA3854, PA3855, pyrC, rnt, PA3836, PA3837, PA0380, PA2542, PA2543, PA1995, PA3850, PA3851, imm2, dauR, PA3865, PA0379, nosR, nosZ, PA3846, PA3847, PA3559, fruA, fadH1, PA3093, PA3844, PA3845, PA2475, ada, PA0378, PA3840, exoS, algE, algG, PA3848, PA3849, PA2800, PA2801, PA3065, PA3066, PA3825, coaD, PA3842, PA1143, oprI, PA2854, maiA, hasAp, hasR, PA3852, PA3853, PA0364, PA3838, PA3839, motA, PA4955, PA2119, PA3830, pepA, PA2022, PA2820, PA2821, PA3491, PA3492, PA3826, PA3827, PA0365, psrA, lexA, PA3417, ldh, PA3828, PA3829, PA0646, PA1135, holC, PA3833, PA2345, PA2346, tgt, queA, PA2481, PA2482, PA2534, PA2535, ndk, PA3808, fabF1, acpP, PA4966, parE, PA4968, PA2114, PA3400, PA3401, PA0715, PA3109, secF, valS, PA3835, PA2348, PA3818, PA3819, truA, fimV, nosL, fpr, PA3499, PA3500, iscA, iscU, iscS, iscR, PA5160, wbpA, wzz, PA1191, PA3470, PA3471, cysE, PA3817, PA3057, pelG, PA4962, PA4963, PA2117, PA1884, PA1187, PA1790, hscA, hscB, PA3485, PA3486, PA3791, leuA, PA3529, PA3530, fdx2, PA2864, PA2865, PA3375, PA3376, PA3795, PA3796, PA1147, PA3131, PA3132, PA3398, PA3399, PA5155, PA5156, PA1791, PA2004, PA3402, PA3403, PA5165, PA5166, PA5167, PA1127, PA3513, PA3514, galU, PA5153, PA5154, PA1786, opdO, PA5150, PA5151, PA5152, PA1785, nosF, nosY, PA3493, PA3494, PA1125, rmlB, rmlD, acnB, PA3489, PA3490, PA1364, rnr, PA2120, rmlA, rmlC, PA3515, PA3516, mvfR, PA1944, bdhA, PA2021, mtlD, PA1134, PA2844, PA2845, PA3383, phnC, PA5157, PA5158, PA5159, PA1784, PA2577, PA2578, mtlY, PA3533, PA3534, nosD, PA2347, PA2568, PA2569, PA1188, PA3404, hasE, PA3509, PA3510, PA2102, PA3497, PA3498, PA2020, PA3483, PA3484, cpdA, PA4970, PA2483, PA2484, PA2107, rhlG, PA3388, PA3501, PA3502, PA2108, PA3390, PA3389, pldA, PA3488, PA5422, PA5423, PA1117, fis, purH, PA2380, pchE, pchR, PA4132, PA4133, purU2, fdhA, PA4150, acoB, PA4779, PA4780, PA4820, PA4821, soxB, soxD, PA1028, PA2581, ltaA, PA5414, glyA1, PA4818, PA4819, PA1036, gbcB, PA5412, PA4222, PA4223, PA4781, PA4782, PA2582, PA2583, PA4121, PA4122, PA2180, pchG, pchF, PA4134, PA4135, PA5081, PA5082, atpE, atpB, PA4136, PA4137, PA5406, PA5407, PA5408, PA4140, PA4141, PA3133, PA4816, PA4817, hpcC, hpcB, PA2179, PA5404, PA5405, tyrS, PA4139, PA1034, PA4148, PA4149, PA2134, ercS', PA4142, PA4143, xcpQ, PA3106, PA0257, acoR, PA4162, PA2135, pqqH, PA3613, PA3614, fdnG, lipC, PA2992, PA2993, pqqE, PA3595, PA3596, potC, potD, PA4152, PA4153, PA2984, PA2985, PA3601, PA3602, PA2802, PA2803, PA3599, PA3600, plsX, rpmF, waaA, PA4989, PA4990, PA1067, dgkA, erdR, PA3580, glpF, PA4984, PA4985, PA1993, fadH2, PA4815, etfB, PA2953, PA4156, PA4157, glpK, glpR, PA3008, PA3009, PA4991, PA4992, ptpA, kdsB, fdhE, PA4822, PA4823, recA, PA3586, PA4154, PA4155, PA3578, PA3579, glpD, glpM, PA4163, PA4164, nalD, PA3575, PA1994, PA1033, PA3618, PA3619, aruI, PA4978, PA0225, fdnI, fdnH, PA3605, PA3606, PA1981, selB, selA, PA2956, PA2957, PA1118, PA3597, PA3598, nqrC, nqrB, PA3589, PA3590, piv, ppiC2, PA3593, PA3594, mexE, fepD, fepG, PA3004, nagZ, ercS, PA3591, PA3592, metR, PA3588, PA4165, PA4166, fruK, fruI, aph, PA4120, PA2178, mutS, fdxA, PA3611, PA3612, PA4993, PA4994, PA2489, PA2490, PA4805, PA4806, PA5409, gbcA, PA3797, PA3798, PA3615, PA3616, PA4167, fpvB, PA5079, PA5080, PA4169, PA4170, PA4803, PA4804, PA2136, PA2414, PA4177, PA4178, PA2419, PA2842, PA2843, hpcG, PA2177, PA4144, PA4145, PA2418, PA5083, PA5084, PA5085, PA4801, PA4802, PA2137, quiP, PA4191, PA4192, PA4171, PA4172, PA2812, PA2813, PA5194, PA5195, PA5196, PA1823, betT1, PA5376, PA1025, PA4173, PA4174, rimK, PA5198, PA1824, PA0938, PA4181, PA4182, PA0343, PA4183, PA4184, PA0326, PA0846, PA0366, amgS, amgR, PA3731, PA3732, PA3748, PA3749, PA1170, rpsU, PA4799, PA4800, ffh, PA3747, PA4179, PA4180, PA3756, PA3757, PA5357, ubiA, PA1030, PA3739, PA3740, fepC, fepB, PA2702, PA2703, PA1062, PA3733, PA3734, PA4189, pqsL, dsbC, xerD, czcA, czcB, PA4187, PA4188, thrC, hom, PA3741, rplS, PA4982, PA4983, xylL, xylZ, PA3714, PA3715, mexI, opmD, PA3727, PA3728, bfiS, PA4198, PA3010, topA, pqqB, PA4193, PA4194, trmD, rimM, PA1076, PA0488, PA3720, nalC, tpx, PA2533, bphP, PA4118, PA2176, lasB, recJ, PA5473, PA5474, PA3722, PA3723, PA3726, PA3718, armR, PA1136, pilZ, holB, PA5401, PA5402, PA5403, lysS, prfB, PA3716, PA3717, exaB, pgsA, PA2804, PA2805, PA4783, PA4784, PA0446, wspE, wspD, PA4199, PA4200, PA3729, PA3730, PA4824, mgtA, PA2175, PA3712, spdH, pelD, pelC, PA4797, PA4798, wspA, PA3709, copS, PA2811, exaC, PA3001, mfd, PA2491, mexT, PA4220, fptA, rpoS, PA3623, PA4795, PA4796, PA4979, PA4980, PA4981, kdsA, potA, potB, PA3754, PA3755, fabG, fabD, PA0443, PA1888, PA3752, PA3753, PA4793, PA4794, pcm, surE, PA4203, ppgL, PA2857, PA2858, eraS, PA1189, mexG, mexH, PA2138, PA3634, eno, PA3750, purT, nqrE, nqrD, PA3628, adhC, PA3632, ygbP, PA4791, PA4792, dxr, cdsA, PA3630, PA3631, PA0589, PA4195, bfiR, PA3758, PA3759, PA1031, rluC, exaA, metZ, purF, PA3775, PA3776, pqqA, phzF1, phzG2, PA3626, ygbB, PA4185, PA4186, PA2963, pabC, accA, dnaE, PA2548, PA2549, lpxA, fabZ, PA4787, PA4788, PA3641, rnhB, PA3760, PA3761, braE, PA2980, lpxK, phzD1, phzE1, opr86, PA3649, cdhC, PA5388, rpsP, PA2485, PA2486, eraR, phzM, phzA1, rne, murB, phzB1, phzC1, PA3003, lpxB, PA3012, foaB, PA1465, lpxD, PA3647, pstC, pstS, PA1038, PA3764, PA3765, PA4218, PA4219, gcdH, guaB, pyrH, PA1037, PA3667, PA3187, PA3188, PA2775, PA2776, PA3663, PA3664, fiuA, pyrG, PA3638, PA4789, PA4790, PA2140, PA3768, guaA, uppS, frr, PA5293, PA5294, PA5295, nqrA, aroP1, PA3766, PA3767, PA2806, PA2807, map, glnD, pchD, PA1890, PA4785, PA4786, PA3659, PA3660, PA3362, amiR, PA3661, PA3662, PA0467, PA2540, PA2541, PA3771, PA3772, uvrC, gacA, PA3665, dapD, PA3787, PA3788, PA2988, PA2989, PA1190, PA3672, plsB, tsf, rpsB, PA3678, PA3679, PA2986, PA2987, PA3773, PA3774, PA2589, PA2590, PA1022, PA1660, spuA, PA5212, gcvP1, PA0271, PA1663, cysS, PA1653, PA0122, pscH, PA0915, PA1970, PA0732, PA1840, cupC1, PA2217, PA0603, PA0825, PA0571, PA5244, PA5245, PA1832, pqsD, PA1814, PA0126, PA1836, PA0916, PA0643, metH, PA1897, PA0647, PA1955, PA1664, folD, gcvH1, gcvT1, PA0623, PA1837, PA0033, PA0664, PA1845, PA1849, PA1185, PA0032, PA1842, PA0270, PA0737, qscR, PA0677, aotM, PA0914, PA0093, spuD, PA0760, betC, PA1810, PA0030, pqsC, glpT, PA5236, PA1964, PA0092, trpD, PA1746, ppiB, PA0310, PA2229, PA0600, PA1839, PA0029, kup, prpC, PA1847, PA0645, PA0097, PA0722, bkdB, rbsA, PA0295, PA1855, PA0670, toxR, qor, PA0669, spuG, PA0718, phnB, PA0640, PA1943, PA1741, PA0115, PA0671, PA0658, PA1139, PA0267, PA0845, aguB, PA1184, pslL, bolA, PA5106, blc, cysW, napC, PA0678, PA0692, PA0738, PA0733, PA0022, PA0709, PA2206, PA0096, PA1768, PA0625, PA1767, PA0698, PA1853, femA, pqsE, PA0614, PA0276, PA1769, lldA, PA0095, PA0100, PA1961, PA0278, PA0021, PA1952, PA0268, pdxA, PA1659, PA5251, PA5252, PA0099, pscL, PA2221, PA0626, PA0786, PA0727, PA0098, vfr, PA1951, PA0751, PA1123, PA0803, cdhR, PA5390, PA5391, PA2211, PA1841, PA0704, PA0673, ostA, PA0617, PA0875, PA0655, pqsA, dgt, PA0629, PA1171, PA0290, PA0700, cmaX, PA0102, PA0606, PA1958, PA0663, PA0602, PA2201, pslN, exbB2, folB, PA0275, PA0724, coaB, PA1772, PA0721, gpuA, PA0696, PA0583, PA0702, PA0274, PA0101, PA0701, PA1661, exbD2, PA0688, PA1956, fda, PA2291, ogt, rbsC, PA5230, PA5231, PA5232, PA0691, cti, PA1953, PA0103, PA0690, PA2307, PA0687, algP, PA5254, PA0686, pscK, PA0689, PA0757, PA0680, PA0685, PA0581, PA0127, PA0684, tyrZ, PA0682, PA1848, hemO, PA0683, katN, PA0578, soxA, soxG, PA0802, phhB, pslK, rbsK, PA1844, PA0128, PA1954, PA1570, apaH, spuB, pruR, PA1138, PA0125, phhC, spuI, PA5216, PA5217, PA5218, gabP, PA0784, PA0659, ksgA, dctA, PA0882, PA5484, ampDh2, PA5486, PA5237, PA5238, rho, PA2090, aguR, thiE, hemL, PA1538, cheZ, cupA1, PA0508, PA1066, cupA5, hcpC, popB, PA4859, PA4860, PA0258, PA4113, PA4114, PA0505, PA1103, PA0130, PA1089, obg, rpmA, PA1978, exsD, PA1201, gacS, cysT, PA1974, slyD, PA1203, PA1575, PA0249, PA5099, hutU, rpmB, PA5317, PA0558, aroE, PA0472, PA1329, PA0943, PA1219, PA0060, hemF, PA0615, PA1572, plcB, PA1577, PA1730, PA0242, PA4564, proB, nrdG, PA1325, PA0816, motD, PA4975, aruH, PA0591, PA0266, PA0820, PA0027, PA0926, PA0639, PA1881, PA5325, PA5326, pslB, PA1579, PA1209, PA0367, PA2340, PA1913, PA0058, PA1761, PA0920, PA1760, flgG, PA1882, recG, PA5346, fgtA, PA1470, PA1711, PA4434, PA4435, PA4430, PA4431, ispB, PA4570, ccmB, PA4440, PA4441, PA4436, PA4437, PA2163, PA1478, PA4571, fklB, PA4438, trpS, PA1361, PA0444, aroK, pilQ, PA2162, PA1363, PA4573, PA4574, PA1468, hisG, murA, PA1467, mltB1, PA1473, PA4575, PA4576, PA4445, algW, PA1063, ccmA, cysN, cysD, PA4577, PA4578, PA4451, pilP, pilO, PA2164, PA1472, PA4579, PA4580, PA0937, hisC1, hisD, PA4452, PA4453, PA1343, rtcR, ptsN, PA4465, PA1344, PA4456, PA4457, PA4582, PA4583, ccmF, PA4458, PA4459, PA4454, PA4455, PA4584, rtcA, PA4466, PA4467, PA1356, PA0448, PA1357, PA1059, PA4460, PA4461, PA1355, PA4586, ccpR, rpoN, PA4463, ccmE, pilN, PA2165, gdhA, PA4589, ccmH, PA4474, PA4475, PA1359, fumC1, PA4471, pra, PA1350, pmbA, PA4473, PA0935, sodM, PA4469, PA4591, PA4592, PA1349, PA4476, cafA, PA1352, PA5052, hslV, hslU, PA2166, PA4593, PA4594, PA4491, PA4492, roxR, roxS, PA1348, PA4595, PA4596, PA4499, PA4500, PA1345, PA1060, ccmG, PA4495, PA4496, PA0450, PA1474, oprJ, mexD, PA4489, PA4490, PA1354, PA5055, phaC1, PA1351, mexC, nfxB, PA4503, PA4504, PA4497, PA4498, morA, glyA3, PA1471, ccmC, PA4517, PA4518, PA4603, PA4604, PA1353, pirA, PA1347, opdP, PA4502, PA4605, PA4606, PA4507, PA4508, PA4607, PA4608, PA1346, PA4521, ampD, PA1370, radA, PA4610, PA1372, PA1057, PA4513, PA4514, PA0449, PA4611, PA4612, PA1371, PA1358, speC, PA4520, katB, PA4515, PA4516, PA5371, betA, PA1374, fabF2, mscL, PA4615, PA4509, PA4510, PA1379, pdxB, PA4616, PA4617, PA4478, mreD, gbdR, PA5381, PA1058, PA1368, PA1377, PA5046, PA5047, PA5048, PA4618, PA4619, PA4523, rplU, rpmE, priA, PA2167, PA5073, PA5074, PA4511, lpxO1, aceK, PA0452, PA4505, PA4506, PA4620, PA4621, pilM, ponA, PA1231, mreB, gatC, PA1232, PA4622, PA4623, PA1235, phaD, mreC, PA4624, PA4625, PA5028, PA5029, PA1236, PA1055, PA1240, gatA, gatB, hprA, PA4627, PA1237, phaC2, PA5059, phaF, PA1233, PA0946, PA4485, PA4486, lysP, PA4629, argS, PA4424, PA4425, PA2170, PA1234, PA4630, PA4631, PA5033, hemE, PA1238, PA5024, metY, PA2168, PA4632, PA4633, sspA, PA4429, PA0451, PA5030, PA5031, PA5032, PA4634, PA4635, PA1239, PA4487, PA4488, PA1056, gltD, gltB, PA4636, PA4637, PA4426, sspB, aprF, PA5026, PA5027, PA2171, PA5071, PA5072, ftsL, PA1243, PA4422, PA4423, PA1242, PA4637a, PA4639, msrA, PA5019, PA1244, braD, PA1230, PA0368, murE, ftsI, aprA, mqoB, PA1245, PA5037, aroB, PA4420, PA4421, PA4642, PA4643, PA5022, PA5023, PA1061, aprI, PA1053, aprD, murG, PA4644, PA4645, ftsW, murD, PA2160, PA0454, PA5020, PA5021, PA2172, rpsI, rplM, aprE, upp, uraA, ampG, PA4394, PA1251, ddlB, murC, PA2159, PA4648, PA4649, PA1255, mraY, murF, PA1252, PA4405, lpxC, PA2158, PA4650, PA4651, ftsZ, aceF, PA5017, relA, PA1256, PA4652, PA4653, PA2157, PA4401, argJ, PA1257, secA, PA4404, PA1262, PA4654, hemH, PA4377, inaA, PA2156, PA1054, PA1260, PA4399, PA4400, PA4656, PA1254, ftsA, ftsQ, PA2155, PA1258, glnE, aceE, PA2173, PA4657, PA4658, PA1259, PA4395, PA4396, PA4387, PA4388, PA4659, phr, speA, PA4390, PA4391, PA4392, PA2154, PA1265, pagL, murI, PA4364, PA4365, groEL, groES, glgB, PA1261, moeB, hemK, panE, PA4398, PA2152, PA1051, PA4379, PA4380, prfA, hemA, PA1270, PA0929, PA4381, PA4382, PA2151, PA1269, PA4371, PA4372, PA4667, PA4668, PA1266, PA4373, PA4374, PA2150, PA1268, PA4375, pncB2, PA1263, ipk, PA1264, xenB, PA4357, cobD, PA4369, icmP, prs, PA4383, PA4384, PA2149, rep, poxB, PA1052, PA0456, PA4671, PA4672, sodB, PA1271, PA1267, PA1229, PA4358, PA4359, PA2148, PA4673, PA4674, PA4361, cobO, PA5382, PA5383, PA1047, PA4362, iciA, cobC, PA4675, PA4676, PA4346, PA4347, PA1280, PA0489, cobQ, waaF, ilvE, PA2174, cobU, PA4677, rimI, bifA, PA4368, PA1274, PA4679, PA4680, PA1048, PA4352, PA4353, PA1284, PA4681, PA4682, cobV, PA1282, PA4354, PA4355, cobP, PA4683, PA4684, PA4350, PA4351, PA1378, PA4685, PA4686, PA1285, PA4348, PA4349, hitA, PA1253, PA4342, PA4343, PA1283, dbpA, hitB, PA4689, PA1290, PA4344, PA4345, PA4690, PA1289, pdxH, PA4340, PA4341, PA1293, PA4338, PA4339, PA1288, PA4691, PA4692, PA1304, ygcA, PA1287, PA4334, PA4335, cyoB, pssA, ilvC, phnX, PA5188, PA5189, PA1972, PA4336, PA4337, ilvH, phnW, PA1291, PA4332, PA4333, PA1292, ilvI, PA4697, PA1050, PA1299, PA0458, PA1883, PA4330, PA4331, PA1300, PA4698, PA4699, PA1306, PA4326, PA4327, PA1297, mrcB, PA4701, cyoA, PA1043, PA4328, pykA, PA4702, PA4703, PA2200, PA1298, PA5185, PA5186, PA5187, PA1829, PA0922, PA1296, PA4324, PA4325, PA1314, cbpA, PA4705, waaG, waaC, PA4320, PA4321, PA4706, PA4707, PA1309, PA5008, waaP, PA1466, mvaT, phuT, PA4709, PA1307, sbcB, PA4317, PA4318, PA4319, phuR, PA4711, tadD, tadC, katE, PA1044, PA4313, purU1, PA1295, PA4712, PA4713, PA1303, PA4322, PA4323, PA1316, pctA, pctB, PA1302, PA4714, PA4715, PA1301, rcpC, flp, PA4716, PA4717, cyoE, pctC, PA4308, PA0457, rnd, PA4718, PA4719, PA4291, PA4292, PA1305, PA1322, creD, trmA, PA4721, PA4311, PA4312, PA1308, PA0468, PA4722, dksA, cyoC, tadB, tadA, PA1312, PA5183, PA5184, PA4724, cbrA, PA0460, cyoD, tadG, PA4298, PA5006, PA5007, cbrB, pcnB, sbcD, PA1315, PA5003, PA5004, PA5005, folK, tadZ, rcpA, betB, betI, panB, panC, cysP, pprA, PA4294, PA1484, phoU, pstB, pstA, PA1313, glcD, glcC, PA1499, recC, PA4286, PA1241, panD, pgi, PA1497, PA4287, PA4288, purC, PA5384, cdhB, cdhA, PA1495, PA4289, PA4290, PA1487, acsB, PA4734, recD, recB, PA4735, PA4736, PA1489, fppA, pprB, PA0459, PA1045, waaL, wapR, PA4737, PA4738, PA5001, PA5002, PA4279, birA, PA1488, PA4739, pnp, msbA, PA4998, PA1323, rpsO, truB, PA2199, PA1490, PA4995, rfaE, PA1065, pykF, PA1208, tpbB, PA0947, PA1324, PA4278, rbfA, PA1492, PA4282, PA2146, PA1491, nusG, secE, infB, nusA, tufB, PA2145, rpoB, PA4746, rplL, rplJ, PA1039, rplA, rplK, PA0462, secG, PA1496, rpsL, rpoC, PA1418, tpiA, glmM, PA1416, folP, ftsH, rpsJ, tufA, PA0924, PA1486, PA5178, PA5179, PA5180, PA1828, ftsJ, PA4753, cobB, rplC, PA1417, PA0236, PA5181, PA5182, PA1827, bdlA, PA4754, greA, PA1485, rpsH, PA1040, PA5176, PA5177, cycH, carB, fusA1, rpsG, PA1425, gbuA, rpsS, rplB, PA4757, carA, PA1420, rplW, rplD, PA0461, PA1041, rplP, dapB, dnaJ, rpsC, rplV, PA1286, PA1419, dnaK, grpE, rplQ, gbuR, rpsQ, rpmC, PA1424, recN, PA1942, fliD, fimL, lasI, rpsN, rplE, fur, omlA, rsaL, PA5174, cysQ, PA1826, PA1434, rpmD, rpsE, lasR, PA4766, PA4767, arcB, arcC, PA1042, rplR, rplF, smpB, PA4769, PA1428, arcD, arcA, PA1825, PA1429, secY, rplO, PA1435, creC, lldP, lldD, rplX, rplN, glgP, rpoA, rpsD, PA1436, PA4772, rpsK, rpsM, PA2143, PA1433, pchA, ssb, PA4773, PA4774, PA1441, PA4233, uvrA, PA2142, PA1440, bfrA, katA, cysM, PA4775, pmrA, phzG1, phzS, PA2141, PA1439, rpmJ, PA1064, pmrB, cueR, PA4128, PA4129, pchC, pchB, PA4130, PA4131, PA1437, PA1035, fliN, creB, fliQ, fliO, flhB, PA1442, PA0486, PA1438, PA1494, fliM, fliR, PA1451, fliP, tolB, flhF, fleN, flhA, PA0466, PA1941, PA1450, PA0510, ung, phzD2, PA2189, PA1578, coxA, PA0254, sucA, sdhC, kefB, PA0962, PA1623, PA0261, PA1617, PA1616, PA1622, PA1624, PA2349, PA2367, PA2368, PA0259, PA1621, PA0256, ldhA, PA1095, PA1613, PA2321, PA1618, PA2328, pscJ, PA1595, PA0902, gpsA, PA2319, PA1611, pcaK, pscE, PA0234, PA0951, PA0240, PA1930, gabD, mucR, PA2212, PA1602, aspS, PA0241, PA1608, PA2352, PA1601, sbp, sdhD, PA1604, fabB, PA2331, fliF, PA0237, PA1830, sucB, PA1603, PA2351, htpG, sdhA, PA2210, PA0253, PA1654, yfiB, PA1745, coxB, PA0853, PA0539, PA1620, PA1665, PA1600, PA1599, PA0544, PA2332, PA1576, PA0549, PA1093, PA0246, PA1743, PA2213, PA1869, PA0243, pcaB, PA1606, PA0569, fleQ, PA2335, PA1667, PA1605, PA1744, PA0953, PA1210, PA2196, PA1872, PA0248, oprD, PA1607, PA0832, PA2309, PA2353, PA1615, PA1619, PA1808, pscC, PA1612, PA0656, PA0262, pscG, PA0251, fabA, PA1206, PA1360, dinB, PA0840, PA0752, prpD, PA2312, pmtA, PA0955, PA1591, PA1906, fliA, PA0533, lepA, PA0950, PA0596, coIII, PA0841, PA1833, argC, PA1215, PA0826, PA1211, PA1593, PA0107, fliI, PA1202, PA0850, PA0961, PA0728, str, sucC, PA0557, PA1742, modC, PA1666, wrbA, PA0954, PA1212, trxB2, PA0163, prpB, PA0794, ruvB, phzE2, PA0864, fliE, PA1854, tolA, sdhB, PA1738, azoR1, PA1859, rpoD, sucD, PA1214, PA1963, PA1929, PA0109, PA0790, PA1463, dnaG, PA0238, PA0813, PA1739, PA0239, fliC, PA1750, PA0851, tolQ, PA1592, PA1458, PA1462, opdH, PA0601, phzC2, PA0909, rimJ, mucB, modB, PA1096, nadB, PA1860, sdsA1, PA1850, PA0635, PA0666, PA0960, fliG, PA0810, PA1669, PA0839, PA2190, PA1464, PA0159, PA1747, braB, PA1459, PA0959, PA0791, fleR, PA1205, PA0827, lpdG, PA0812, PA0554, PA0608, PA1851, PA0747, cheY, PA0536, plcR, PA1668, PA1852, PA0160, lepB, PA0842, PA0925, PA1864, PA1749, PA1856, PA1866, PA1641, PA0855, tolR, PA0637, PA0781, pcaC, gltA, PA0819, PA1925, trpC, PA2086, PA0834, pta, PA1213, algU, PA0575, PA0957, pobA, PA1748, PA1926, ruvC, PA0561, PA1204, PA0157, PA0743, pcaR, PA1598, PA1923, rnc, PA0158, dgcB, PA5400, PA0847, PA1113, pcaG, PA0859, PA0754, PA1965, PA0156, pcaD, PA0860, PA0788, pmpR, PA0644, PA0968, PA0171, PA1116, PA1648, aroQ2, PA1594, PA1892, motC, PA0661, PA0543, PA0695, PA1656, pvdA, PA4826, PA4827, PA0184, rpiA, nrdD, pbpC, PA2477, PA2478, PA4900, mdlC, PA0528, PA0329, dnr, PA1922, hcnB, PA0328, PA4866, ureB, PA0526, PA2365, pvdO, PA1227, PA0525, PA0335, PA2354, norB, PA2479, PA2480, hcnC, hcnA, nirF, PA0334, norC, PA2364, pvdN, PA0522, PA0862, aotQ, PA0521, ansB, PA1226, PA1875, ureA, PA0333, pncB1, nadE, nirQ, PA2363, PA2393, nirS, PA0863, aer2, nirM, lgt, PA2362, opmQ, pvdP, hpd, PA2359, PA2360, PA5090, hutG, PA1340, PA1876, ptsP, PA4877, PA4878, PA0713, PA2361, pvdT, mliC, fbp, gloA3, PA1331, PA1228, PA5088, PA5089, PA0338, aotP, PA0716, fpvI, aroP2, pslJ, PA0719, PA4828, lpd3, PA0187, PA0173, PA0714, fpvR, PA0861, pvdQ, PA0712, ggt, PA1874, PA4889, desT, PA0339, PA4902, PA4903, PA0726, pvdR, gcp, PA5087, PA1921, PA4830, pslI, stp1, PA4887, desB, PA1655, PA0370, PA0175, msuE, PA2366, dht, PA0530, ubiH, pepP, PA0529, ygdP, PA5219, PA5220, PA2274, ureE, ureF, PA2225, vqsM, soxR, qteE, PA2594, PA2595, PA2596, PA2597, PA2598, PA2599, PA2600, PA2601, PA2602, PA2603, PA2604, PA2605, PA2606, PA2607, PA2608, PA2609, PA2610, cysG, serS, PA2613, lolA, ftsK, trxB1, aat, PA2618, infA, clpA, PA2621, cspD, icd, idh, PA2625, trmU, PA2627, PA2628, lecA, purB, PA2630, PA2631, PA2632, PA2633, aceA, PA2635, PA2636, nuoA, nuoB, nuoD, nuoE, nuoF, nuoG, nuoH, PA4834, PA4835, nuoI, nuoJ, nuoK, nuoL, nuoM, nuoN, PA2650, PA2651, PA2652, PA2653, PA2654, PA2655, PA2656, PA2657, PA2658, PA2659, PA2660, PA2661, PA2662, ppyR, fhp, PA2665, PA2666, PA2667, PA2669, PA2670, PA2671, PA2672, PA2673, PA2674, PA2675, PA2676, PA2677, PA2678, PA2679, PA3197, PA3198, PA3230, PA3231, PA3232, PA3233, PA3234, PA3235, PA3236, PA3237, PA3228, PA3229, PA3238, PA3239, PA3240, PA3241, PA3242, minC, minD, minE, rluA, PA3247, PA3248, PA3249, PA3250, PA3251, PA3252, PA3253, PA3254, PA3255, PA3256, prc, PA3258, PA3259, PA3260, PA3261, PA3262, PA3263, PA3264, PA3265, capB, PA3267, PA3268, PA3269, PA3270, PA3271, PA3272, PA3273, PA3274, PA3275, PA3276, PA3277, PA3278, oprP, oprO, PA3281, PA3282, PA3283, PA3284, PA3285, PA3286, PA3287, PA3288, PA3289, PA3290, PA3291, PA3292, PA3293, PA3294, PA3295, phoA, PA3297, PA3298, fadD1, PA3226, ppiA, fadD2, PA3301, PA3302, PA3303, PA3304, PA3305, PA3306, PA3307, PA3308, PA3309, PA3310, PA3311, PA3312, PA3313, PA3314, PA3315, PA3316, PA3317, PA3318, plcN, PA3320, PA3321, PA3322, PA3323, PA3324, PA3325, PA3326, PA3327, PA3328, PA3329, PA3330, PA3331, PA3332, fabH2, PA3334, PA3335, PA3336, rfaD, PA3338, plpD, PA3340, PA3341, PA3342, PA3343, recQ, PA3345, PA4881, PA4882, PA3346, PA3347, PA3348, PA3349, PA3350, flgM, PA3352, PA3353, PA3354, PA3355, PA3356, dsdA, PA3358, PA3359, PA3360, lecB, PA3224, PA3225, PA3199, PA3200, PA2558, PA2559, PA3209, trkH, PA3207, PA3208, PA3213, PA3214, PA3215, PA3216, PA3203, PA3204, PA3205, PA3206, PA3219, PA3220, dsbG, PA3211, PA3212, csaA, PA3222, azoR3, cyaB, PA2917, PA2918, PA2882, PA2883, himD, rpsA, PA2712, PA2713, PA2900, PA2901, PA2898, PA2899, PA2729, PA2919, PA2920, PA3201, PA3202, PA2726, hisM, hisP, PA3180, PA3181, wbpG, hisF2, wbpM, PA3142, pyrF, PA2877, atuG, atuH, hisH2, wzx, PA2911, PA2912, wbpD, mttC, PA2867, PA2915, PA2916, PA2870, PA2871, PA2894, PA2895, PA3136, PA3137, ohr, efp, ligT, wbpH, atuA, atuB, PA2714, PA2715, PA2708, cysK, PA2874, PA2875, PA2722, PA2723, PA3184, PA3185, PA2848, ohrR, PA2698, PA2699, PA2734, PA2735, PA2921, PA2922, PA2730, PA2868, PA2869, PA3172, PA3173, PA2852, PA3127, PA3128, PA2902, cobJ, PA3125, ibpA, PA3157, wbpB, PA2872, PA2873, PA2913, PA2914, gltX, PA3135, PA2724, PA2725, PA2906, wzy, wbpE, cif, PA2935, PA2706, PA2707, PA2933, PA2736, gltS, PA3177, lipA, lipH, PA2940, PA2941, PA2880, PA2881, PA2716, cpo, uvrB, PA3139, PA3170, ubiG, PA2878, PA2879, PA2927, PA2928, cobL, cbiD, pgl, zwf, PA3143, PA3174, PA3175, PA2909, PA2910, cobI, cobH, PA2696, PA2697, wbpJ, wbpI, hisC2, hisJ, hisQ, wbpL, wbpK, pheA, serC, atuC, atuD, PA3140, PA3178, PA3179, PA2732, PA2733, atuE, atuF, PA2694, PA2695, PA2884, atuR, PA2718, PA2719, PA2936, PA2937, PA2759, PA2760, PA3084, PA3085, PA2564, PA2565, PA2754, eco, PA2763, PA2764, PA3086, PA3087, PA2761, PA2762, PA2562, PA2563, PA2752, PA2753, PA3088, PA3089, PA2560, PA2561, PA2765, PA2766, PA2554, PA2555, PA2773, PA2774, PA3091, PA2556, PA2557, PA2771, PA2772, PA2680, PA2681, PA2795, tal, xcpU, PA2785, PA2786, PA2682, PA2683, PA3094, PA2779, PA2780, pfeR, pfeS, xcpZ, PA4831, PA4832, PA4833, PA2781, PA2782, PA2767, PA2768, PA2789, PA2790, xcpW, xcpV, xcpY, xcpX, PA2777, PA2778, cpg2, PA2788, pfeA, PA2689, PA2791, PA2792, oprB, PA2896, PA2897, PA2938, PA2939, PA2756, PA2566, PA2567, PA2704, PA2705, PA2929, PA2930, gyrA, PA3169, PA3116, asd, PA2814, PA2815, PA2834, PA2835, PA2498, PA2499, htpX, PA2831, leuB, PA3119, PA2502, PA2503, tpm, PA2833, leuD, PA2836, PA2837, catR, PA2511, PA2840, PA2841, PA2692, PA2693, leuC, PA3122, gapA, PA3196, cobN, PA2945, PA2942, PA2943, PA2946, PA2947, PA2417, pvdL, pvdS, pvdG, PA2422, PA2423, PA2428, PA2431, PA2429, PA2430, PA2427, PA2433, PA2435, PA2436, PA2434, bexR, PA2438, cobM, PA2949, PA2474, pvdH, PA2469, foxA, PA2415, treA, PA3053, PA3054, PA3051, PA3052, rmf, pyrD, PA3045, PA3046, PA3055, PA3056, PA3043, PA3044, PA3041, PA3042, PA3037, PA3038, PA3047, PA3048, PA3035, PA3036, PA2500, PA2501, mexF, oprN, PA2496, PA2497, PA2526, PA2527, PA2487, PA2488, antA, xylS, czcC, PA2523, PA2690, PA2691, PA2546, PA2547, PA3189, PA3190, xylY, xylX, PA2550, PA2551, PA3191, gltR, glk, edd, PA4879, PA4880, foxI, PA2461, PA2462, PA2471, PA2472, PA2453, PA2473, gtdA, PA2448, PA2449, PA2450, glyA2, PA2447, gcvP2, gcvH2, PA2440, sdaA, PA2950, etfA, PA2441, gcvT2, PA2437, PA2439, PA2528, PA2529, PA2458, PA2459, PA2750, PA2751, PA2538, PA2539, PA2460, PA2757, PA2758, PA2455, PA3081, gbt, PA2454, pepN, PA2737, himA, PA2463, PA1024, PA2464, PA2465, PA3079, PA3080, PA2746, PA2747, PA2457, PA2748, endA, catC, catB, pheT, pheS, foxR, thrS, PA2745, PA3077, PA3078, PA3033, PA3034, antB, antC, mobA, PA3031, rplT, PA3039, PA3040, PA3022, PA3023, PA2504, opdT, PA2421, PA0192, oprL, PA0806, PA1007, PA0371, PA1639, PA1005, pcrV, PA1533, PA0556, PA0372, ccoN1, PA1536, kdpC, PA1341, PA0217, PA1522, cysB, PA1551, anr, ccoO1, kdpB, PA2087, PA1638, kdpE, PA1549, PA1519, PA2314, ftsY, PA2322, PA1547, PA0269, PA5456, PA5457, PA0279, PA1672, PA2330, kdpF, PA1680, kdpD, PA2333, moaA2, PA5103, PA5104, hutC, mdcC, PA1108, rmd, PA5455, PA0193, aruD, PA1539, PA2315, ccoP1, PA1545, PA1877, PA2323, PA1506, PA2324, ccoO2, PA0277, PA1504, PA2316, hemN, PA2325, kdpA, PA2326, PA1550, PA1541, PA1106, PA1542, speE, PA1111, PA1676, PA5534, PA5535, ccoP2, PA2334, mtlR, PA1540, stk1, PA2339, PA1548, PA1751, PA2369, PA2327, PA1531, PA1012, ftsE, pslH, exbB1, hcpA, aruG, PA1566, PA1109, PA1192, PA2338, PA1631, wbpW, gmd, trpI, PA0273, ftsX, PA0340, dnaX, nadA, PA1937, PA0190, pqsB, PA1520, pscP, PA0191, PA1679, PA2317, PA1675, PA2198, PA1628, PA1508, PA0203, PA1383, PA0215, PA1195, PA2318, PA1521, PA1526, PA2329, wzt, wzm, PA1014, PA0189, PA1403, PA2336, pscQ, gntR, PA1627, rpoH, PA1511, PA1752, PA2089, alc, PA1753, cls, PA5395, PA1404, PA2370, PA0377, PA2184, ccoQ2, ccoQ1, PA4724.1
原始数据
| Sample name | Organism | Experiment title | Sample type | Library instrument | Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| {{attr}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| {{ dataList.sampleTitle }} | {{ dataList.organism }} | {{ dataList.expermentTitle }} | {{ dataList.sampleType }} | {{ dataList.libraryInstrument }} | {{ showAttributeName(index,attr,dataList.attributes) }} | |||||||||||||||||||||||||||||||||||||||||||||||||
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| {{ list.authorName }} {{ list.authorName }} |
