| Type | Description |
|---|---|
| Definition | transcriptional regulator |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 11:16:00 | Transcriptomics analysis confirmed the primary mechanism of NalD action-a loss-of-function mutation that caused constitutive overexpression of the MexAB-OprM efflux system-which lead to aztreonam resistance but, surprisingly, had no fitness cost in the absence of the antibiotic. | 31860667 |
| 2017-07-29 12:54:00 | findings show novobiocin binds directly to NalD, which leads NalD to dissociate from the DNA promoter and de-represses the expression of the MexAB-OprM pump; solved the crystal structure of NalD at a resolution of 2.90 A | 26844397 |
| 2010-01-21 00:00:00 | NalD directly controlls mexAB-oprM expression from a second promoter. | 17028276 |
| 2010-01-21 00:00:00 | clinical strains overexpressing OprM but lacking mutations in mexR or nalC were also shown to carry mutations in PA3574 | 15855496 |
| 2006-10-17 10:57:00 | In this study, the nalD gene was shown to be encode a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa. | 17028276 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
Q9HY46_PSEAE
UniprotKB:
Q9HY46
UniParc:
UPI00000C5A74
EMBL:
AE004091
EnsemblGenome:
PA3574
KO:
pae:PA3574
|
| Nucleutide sequences |
EMBL-CDS:
AAG06962.1
|
| Protein sequencees |
RefSeq:
NP_252264.1
|
| Others |
UniRef100:
UniRef100_A0A072ZQ34
UniRef90:
UniRef90_A0A072ZQ34
UniRef50:
UniRef50_A0A072ZQ34
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31860667 |
PLoS Comput Biol Jinyuan Yan , Henri Estanbouli , Chen Liao , Wook Kim , Jonathan M Monk , Rayees Rahman , Mini Kamboj , Bernhard O Palsson , Weigang Qiu , Joao B Xavier |
2019-12-01 | - |
| 26844397 |
Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa. Mol. Microbiol. Weizhong Chen , Dan Wang , Wenquan Zhou , Hong Sang , Xichun Liu , Zhiyun Ge , Jin Zhang , Lefu Lan , Cai-Guang Yang , Hao Chen |
2016-06-01 | - |
| 18978025 |
Nucleic Acids Res. Geoffrey L Winsor , Thea Van Rossum , Raymond Lo , Bhavjinder Khaira , Matthew D Whiteside , Robert E W Hancock , Fiona S L Brinkman |
2009-01-01 |
PA2755a,
PA4636a,
PA0032a,
PA0041a,
PA0103a,
PA0306a,
PA0367a,
PA0451a,
PA0701a,
PA0736a,
PA0788a,
PA0951a,
PA1019a,
PA1052a,
PA1112a,
PA1112b,
PA1424a,
PA1428a,
PA1483a,
PA1578a,
PA1643a,
PA1797a,
PA1833a,
PA1837a,
PA1866a,
PA2118a,
PA2142a,
PA2173a,
PA2312a,
PA2559a,
PA2746a,
PA2747a,
PA2750a,
PA2754a,
PA2763a,
PA2772a,
PA3089a,
PA3303a,
PA3403a,
PA3440a,
PA3574a,
PA3733a,
PA3865a,
PA3886a,
PA3963a,
PA3969a,
PA4027a,
PA4108a,
PA4145a,
PA4313a,
PA4360a,
PA4635a,
PA4690a,
PA5183a,
PA5252a,
PA5440a,
PA0457.1,
pyoS5,
PA1021,
PA0123,
PA0891,
PA1020,
PA0440,
PA0007,
lptA,
PA0116,
PA0119,
PA1159,
PA0439,
codB,
PA0878,
PA2296,
PA0512,
PA0118,
codA,
PA1734,
PA0848,
PA1168,
cmpX,
PA0436,
PA0699,
PA0305,
PA0753,
PA0049,
PA1870,
PA0628,
PA1831,
PA0624,
PA0708,
PA0435,
PA0434,
flgB,
arsC,
PA5108,
PA5109,
PA0978,
PA0919,
PA5340,
PA5341
|
| 17028276 |
nalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa. J. Bacteriol. Yuji Morita , Lily Cao , Virginia C Gould , Matthew B Avison , Keith Poole |
2006-12-01 |
nalD
|
| 17015649 |
J. Bacteriol. Ryan T Cirz , Bryan M O'Neill , Jennifer A Hammond , Steven R Head , Floyd E Romesberg |
2006-10-01 |
PA2755a,
PA4636a,
PA0032a,
PA0041a,
PA0103a,
PA0306a,
PA0367a,
PA0451a,
PA0701a,
PA0736a,
PA0788a,
PA0951a,
PA1019a,
PA1052a,
PA1112a,
PA1112b,
PA1424a,
PA1428a,
PA1483a,
PA1578a,
PA1643a,
PA1797a,
PA1833a,
PA1837a,
PA1866a,
PA2118a,
PA2142a,
PA2173a,
PA2312a,
PA2559a,
PA2746a,
PA2747a,
PA2750a,
PA2754a,
PA2763a,
PA2772a,
PA3089a,
PA3303a,
PA3403a,
PA3440a,
PA3574a,
PA3733a,
PA3865a,
PA3886a,
PA3963a,
PA3969a,
PA4027a,
PA4108a,
PA4145a,
PA4313a,
PA4360a,
PA4635a,
PA4690a,
PA5183a,
PA5252a,
PA5440a,
PA0457.1,
pyoS5,
PA1021,
PA0123,
PA0891,
PA1020,
PA0440,
PA0007,
lptA,
PA0116,
PA0119,
PA1159,
PA0439,
codB,
PA0878,
PA2296,
PA0512,
PA0118,
codA,
PA1734,
PA0848,
PA1168,
cmpX,
PA0436,
PA0699,
PA0305,
PA0753,
PA0049,
PA1870,
PA0628,
PA1831,
PA0624,
PA0708,
PA0435,
PA0434,
flgB,
arsC,
PA5108,
PA5109,
PA0978,
PA0919,
PA5340,
PA5341
|
| 16030221 |
Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. J. Bacteriol. Kelli L Palmer , Lauren M Mashburn , Pradeep K Singh , Marvin Whiteley |
2005-08-01 |
PA2755a,
PA4636a,
PA0032a,
PA0041a,
PA0103a,
PA0306a,
PA0367a,
PA0451a,
PA0701a,
PA0736a,
PA0788a,
PA0951a,
PA1019a,
PA1052a,
PA1112a,
PA1112b,
PA1424a,
PA1428a,
PA1483a,
PA1578a,
PA1643a,
PA1797a,
PA1833a,
PA1837a,
PA1866a,
PA2118a,
PA2142a,
PA2173a,
PA2312a,
PA2559a,
PA2746a,
PA2747a,
PA2750a,
PA2754a,
PA2763a,
PA2772a,
PA3089a,
PA3303a,
PA3403a,
PA3440a,
PA3574a,
PA3733a,
PA3865a,
PA3886a,
PA3963a,
PA3969a,
PA4027a,
PA4108a,
PA4145a,
PA4313a,
PA4360a,
PA4635a,
PA4690a,
PA5183a,
PA5252a,
PA5440a,
PA0457.1,
pyoS5,
PA1021,
PA0123,
PA0891,
PA1020,
PA0440,
PA0007,
lptA,
PA0116,
PA0119,
PA1159,
PA0439,
codB,
PA0878,
PA2296,
PA0512,
PA0118,
codA,
PA1734,
PA0848,
PA1168,
cmpX,
PA0436,
PA0699,
PA0305,
PA0753,
PA0049,
PA1870,
PA0628,
PA1831,
PA0624,
PA0708,
PA0435,
PA0434,
flgB,
arsC,
PA5108,
PA5109,
PA0978,
PA0919,
PA5340,
PA5341
|
| 15995206 |
J. Bacteriol. Prabhakar Salunkhe , Catherine H M Smart , J Alun W Morgan , Stavroula Panagea , Martin J Walshaw , C Anthony Hart , Robert Geffers , Burkhard Tümmler , Craig Winstanley |
2005-07-01 |
PA2755a,
PA4636a,
PA0032a,
PA0041a,
PA0103a,
PA0306a,
PA0367a,
PA0451a,
PA0701a,
PA0736a,
PA0788a,
PA0951a,
PA1019a,
PA1052a,
PA1112a,
PA1112b,
PA1424a,
PA1428a,
PA1483a,
PA1578a,
PA1643a,
PA1797a,
PA1833a,
PA1837a,
PA1866a,
PA2118a,
PA2142a,
PA2173a,
PA2312a,
PA2559a,
PA2746a,
PA2747a,
PA2750a,
PA2754a,
PA2763a,
PA2772a,
PA3089a,
PA3303a,
PA3403a,
PA3440a,
PA3574a,
PA3733a,
PA3865a,
PA3886a,
PA3963a,
PA3969a,
PA4027a,
PA4108a,
PA4145a,
PA4313a,
PA4360a,
PA4635a,
PA4690a,
PA5183a,
PA5252a,
PA5440a,
PA0457.1,
pyoS5,
PA1021,
PA0123,
PA0891,
PA1020,
PA0440,
PA0007,
lptA,
PA0116,
PA0119,
PA1159,
PA0439,
codB,
PA0878,
PA2296,
PA0512,
PA0118,
codA,
PA1734,
PA0848,
PA1168,
cmpX,
PA0436,
PA0699,
PA0305,
PA0753,
PA0049,
PA1870,
PA0628,
PA1831,
PA0624,
PA0708,
PA0435,
PA0434,
flgB,
arsC,
PA5108,
PA5109,
PA0978,
PA0919,
PA5340,
PA5341
|
| 15908409 |
Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa. Infect. Immun. M J Filiatrault , V E Wagner , D Bushnell , C G Haidaris , B H Iglewski , L Passador |
2005-06-01 |
PA2755a,
PA4636a,
PA0032a,
PA0041a,
PA0103a,
PA0306a,
PA0367a,
PA0451a,
PA0701a,
PA0736a,
PA0788a,
PA0951a,
PA1019a,
PA1052a,
PA1112a,
PA1112b,
PA1424a,
PA1428a,
PA1483a,
PA1578a,
PA1643a,
PA1797a,
PA1833a,
PA1837a,
PA1866a,
PA2118a,
PA2142a,
PA2173a,
PA2312a,
PA2559a,
PA2746a,
PA2747a,
PA2750a,
PA2754a,
PA2763a,
PA2772a,
PA3089a,
PA3303a,
PA3403a,
PA3440a,
PA3574a,
PA3733a,
PA3865a,
PA3886a,
PA3963a,
PA3969a,
PA4027a,
PA4108a,
PA4145a,
PA4313a,
PA4360a,
PA4635a,
PA4690a,
PA5183a,
PA5252a,
PA5440a,
PA0457.1,
pyoS5,
PA1021,
PA0123,
PA0891,
PA1020,
PA0440,
PA0007,
lptA,
PA0116,
PA0119,
PA1159,
PA0439,
codB,
PA0878,
PA2296,
PA0512,
PA0118,
codA,
PA1734,
PA0848,
PA1168,
cmpX,
PA0436,
PA0699,
PA0305,
PA0753,
PA0049,
PA1870,
PA0628,
PA1831,
PA0624,
PA0708,
PA0435,
PA0434,
flgB,
arsC,
PA5108,
PA5109,
PA0978,
PA0919,
PA5340,
PA5341
|
| 15855496 |
Antimicrob. Agents Chemother. Mara L Sobel , Didier Hocquet , Lily Cao , Patrick Plesiat , Keith Poole |
2005-05-01 |
nalD
|
| 15716452 |
Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J. Bacteriol. Thomas Bovbjerg Rasmussen , Thomas Bjarnsholt , Mette Elena Skindersoe , Morten Hentzer , Peter Kristoffersen , Manuela Köte , John Nielsen , Leo Eberl , Michael Givskov |
2005-03-01 |
PA2755a,
PA4636a,
PA0032a,
PA0041a,
PA0103a,
PA0306a,
PA0367a,
PA0451a,
PA0701a,
PA0736a,
PA0788a,
PA0951a,
PA1019a,
PA1052a,
PA1112a,
PA1112b,
PA1424a,
PA1428a,
PA1483a,
PA1578a,
PA1643a,
PA1797a,
PA1833a,
PA1837a,
PA1866a,
PA2118a,
PA2142a,
PA2173a,
PA2312a,
PA2559a,
PA2746a,
PA2747a,
PA2750a,
PA2754a,
PA2763a,
PA2772a,
PA3089a,
PA3303a,
PA3403a,
PA3440a,
PA3574a,
PA3733a,
PA3865a,
PA3886a,
PA3963a,
PA3969a,
PA4027a,
PA4108a,
PA4145a,
PA4313a,
PA4360a,
PA4635a,
PA4690a,
PA5183a,
PA5252a,
PA5440a,
PA0457.1,
pyoS5,
PA1021,
PA0123,
PA0891,
PA1020,
PA0440,
PA0007,
lptA,
PA0116,
PA0119,
PA1159,
PA0439,
codB,
PA0878,
PA2296,
PA0512,
PA0118,
codA,
PA1734,
PA0848,
PA1168,
cmpX,
PA0436,
PA0699,
PA0305,
PA0753,
PA0049,
PA1870,
PA0628,
PA1831,
PA0624,
PA0708,
PA0435,
PA0434,
flgB,
arsC,
PA5108,
PA5109,
PA0978,
PA0919,
PA5340,
PA5341
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员