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881789 lasR

881789

lasR

transcriptional regulator LasR

protein-coding

Pseudomonas aeruginosa PAO1

基因描述

Type Description
Definition transcriptional regulator LasR

研究结论

Date Results Publications
2020-05-16 10:10:00 Studied association of Pseudomonas aeruginosa fitness in low oxygen with transcriptional regulator LasR (lasR)loss of function mutation and transcriptional regulator Anr (Anr)/hemerythrin interactions. Results suggest the success of P. aeruginosa in chronic infections is in part through its propensity to lose LasR functionality resulting in increased microoxic fitness. 31980538
2020-02-08 10:11:00 Inactivation of LasR protein (lasR) of Pseudomonas aeruginosa does not block the quorum-sensing (QSR), nor impairs the virulence, and that even a lasR RhlR protein (rhlR) double mutant presents residual virulence, even lacking the production of virulence factors. These results show that the inhibition of either lasR or rhlR is not a straightforward approach to blocking virulence, due to the great complexity of the QSR. 30707095
2019-11-02 11:54:00 These results support the hypothesis that conventional QS hierarchy can be smashed by naturally occurring lasR mutation in clinical P. aeruginosa isolates and that complex QS hierarchy may play a role in maintaining infection of this opportunistic pathogen. 30190495
2019-08-03 11:35:00 Codon-usage frequency mediated SNPs selection in lasR gene of cystic fibrosis Pseudomonas aeruginosa isolates. 31178047
2017-09-23 13:17:00 rhlR/lasR knockout increased the susceptibility of Pseudomonas aeruginosa towards polymyxin B-azithromycin combination via influencing quorum sensing. 28096154

名称对应

Type IDs
Gene
UniProtKB-ID: LASR_PSEAE
UniprotKB: P25084
UniParc: UPI000012E231
EMBL: M59425, D30812, D30813, AE004091
EnsemblGenome: PA1430
KO: pae:PA1430
Nucleutide sequences
EMBL-CDS: BAA06490.1, BAA06489.1, AAA25874.1, AAG04819.1
EnsemblGenome_TRS: AAG04819
Protein sequencees
EnsemblGenome_PRO: AAG04819
RefSeq: NP_250121.1
Others
UniRef100: UniRef100_P25084
UniRef90: UniRef90_P25084
UniRef50: UniRef50_P25084

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