lasA - protease LasA-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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878260 lasA

基因描述

Type	Description
Definition	protease LasA

研究结论

Date	Results	Publications
2020-06-27 11:56:00	LasB, PIV, and LasA are activated postsecretionally in a cascading manner in which the initial activation of LasB was controlled tightly by quorum sensing (QS) at the protein level in addition to the well-known transcriptional control of these proteases by QS	31727738
2010-04-12 12:17:00	crystal structures of active LasA as a complex with tartrate and in the uncomplexed form. While the overall fold resembles that of the other M23 family members, the LasA active site is less constricted and utilizes a different set of metal ligands.	20026068
2010-01-21 00:00:00	These data show that SP-D can contribute to the clearance of P. aeruginosa from the healthy ocular surface and that proteases can compromise that clearance.	19349424
2010-01-21 00:00:00	Data suggest that these clustered residues in the propeptide may play an important role in promoting the correct protein conformation of the mature LasA protease domain.	17351039

名称对应

Type	IDs
Gene	UniProtKB-ID: LASA_PSEAE UniprotKB: P14789 UniParc: UPI000012E22F EMBL: M20982, X55904, U68175, AE004091 EnsemblGenome: PA1871 KO: pae:PA1871
Nucleutide sequences	EMBL-CDS: AAC12656.1, AAA25873.1, AAG05260.1, CAA39397.1 EnsemblGenome_TRS: AAG05260
Protein sequencees	EnsemblGenome_PRO: AAG05260 RefSeq: NP_250562.1
Others	UniRef100: UniRef100_P14789 UniRef90: UniRef90_P14789 UniRef50: UniRef50_P14789

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mRNA

Protein

UniprotKB

Description

Refseq

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Ensembl: {{protein.nucleotideEnsembl}}

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Ensembl: {{protein.proteinEnsembl}}

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Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

Status: {{protein.status}}

Location

( {{protein.positionStart}}..{{protein.positionEnd}} )

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Pubmed编号	文献信息	发表日期	相关基因
31727738	Quorum sensing-dependent post-secretional activation of extracellular proteases in Pseudomonas aeruginosa. J Biol Chem Xi-Hui Li , Joon-Hee Lee	2019-12-20	-
20026068	Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases. J Mol Biol James Spencer , Loretta M Murphy , Rebecca Conners , Richard B Sessions , Steven J Gamblin	2010-03-05	-
19349424	Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model. Infect. Immun. James J Mun , Connie Tam , David Kowbel , Samuel Hawgood , Mitchell J Barnett , David J Evans , Suzanne M J Fleiszig	2009-06-01	Sftpd, lasA, aprA
18978025	Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Nucleic Acids Res. Geoffrey L Winsor , Thea Van Rossum , Raymond Lo , Bhavjinder Khaira , Matthew D Whiteside , Robert E W Hancock , Fiona S L Brinkman	2009-01-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
17351039	Identification of critical residues in the propeptide of LasA protease of Pseudomonas aeruginosa involved in the formation of a stable mature protease. J. Bacteriol. Kerian K Grande , Jean K Gustin , Efrat Kessler , Dennis E Ohman	2007-06-01	lasA
17015649	Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. J. Bacteriol. Ryan T Cirz , Bryan M O'Neill , Jennifer A Hammond , Steven R Head , Floyd E Romesberg	2006-10-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
16030221	Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. J. Bacteriol. Kelli L Palmer , Lauren M Mashburn , Pradeep K Singh , Marvin Whiteley	2005-08-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
15995206	A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. J. Bacteriol. Prabhakar Salunkhe , Catherine H M Smart , J Alun W Morgan , Stavroula Panagea , Martin J Walshaw , C Anthony Hart , Robert Geffers , Burkhard TÃ¼mmler , Craig Winstanley	2005-07-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
15908409	Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa. Infect. Immun. M J Filiatrault , V E Wagner , D Bushnell , C G Haidaris , B H Iglewski , L Passador	2005-06-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
15716452	Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J. Bacteriol. Thomas Bovbjerg Rasmussen , Thomas Bjarnsholt , Mette Elena Skindersoe , Morten Hentzer , Peter Kristoffersen , Manuela KÃ¶te , John Nielsen , Leo Eberl , Michael Givskov	2005-03-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341

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