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882341 aceA

882341

aceA

isocitrate lyase

protein-coding

Pseudomonas aeruginosa PAO1

基因描述

Type Description
Definition isocitrate lyase

研究结论

Date Results Publications
2019-09-14 10:14:00 Expression of aceA gene, encoding isocitrate lyase (ICL), in Pseudomonas aeruginosa is upregulated under H2O2-induced oxidative stress and under iron-limiting conditions. The enzymatic activities of ICL and isocitrate dehydrogenase have opposite responses under different iron conditions, suggesting that the glyoxylate shunt (GS) is important under iron-limiting conditions. 29465342
2013-11-23 11:17:00 These results indicated that the N214 residue is essential for catalytic function, while mutating the Q211, E219, and Q221 residues impairs its catalytic and thermostability properties. 23338961
2010-07-19 12:23:00 RpoN negatively regulates aceA activity. 20093293
2010-01-21 00:00:00 The PAO1 isocitrate lyase (ICL) mutant was less virulent in the rat lung infection model, indicating that ICL is required for the pathogenesis of P. aeruginosa in mammals 18524916
2010-01-21 00:00:00 AceA gene encodes isocitrate lyase involved in the assimilation of acetate, acyclic monoterpenes of the citronellol family, alkanols, and leucine, in which the final intermediary acetyl-coenzyme A may be channelled to the glyoxylate shunt. 17319879

名称对应

Type IDs
Gene
UniProtKB-ID: ACEA_PSEAE
UniprotKB: Q9I0K4
UniParc: UPI00000C577B
EMBL: AE004091
EnsemblGenome: PA2634
KO: pae:PA2634
Nucleutide sequences
EMBL-CDS: AAG06022.1
EnsemblGenome_TRS: AAG06022
Protein sequencees
EnsemblGenome_PRO: AAG06022
RefSeq: NP_251324.1
Others
UniRef100: UniRef100_Q9I0K4
UniRef90: UniRef90_Q9I0K4
UniRef50: UniRef50_O50078

全选

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研究热度

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